I have posted about resveratrol in Advanced forum section. I have been taking about 1500 quercetin + 150 mg resveratrol ed, for about a week. Divided in two doses.

For the first few days I felt great. Now, I feel as though my libido is shutdown, feeling unhappy, and irritatable in general. In short, I feel depressed.

What I feel is pure, unadulterated "down" feeling, divorced from any cause. I can trace the thought processes which triggered the mood. I also know those thoughts, however, have no significance in my life. I dismiss the thoughts, but the mood remains.

The fact that I am getting leaner somehow seems unimportant.

That reallly sucks,I was pretty optimistic about your new trial w/those supps.

Are you sure it is those supps that's causing the depression?

I am also in caloric deficit. I wonder if this will change as I eat more.

Yes,I gathered you're cutting in a cal deficit but are you stating that maybe eating more will effect the shitty mood?

I don't see how these supps would cause depression,E/C for one can but this stack is nothing like that in any way I can conceive.

Another thing,how readily apparent is the b/f loss from this combo and have you increased cardio or introduced any other variables that may be enhancing fat loss other than this stack?

I'm pretty much always in a "shity" mood anyway so I'll give this a try,but only f it certainly is making you leaner.

Colin:

I think it is possible that resveratrol is causing my body to initiate a stress response to hunger. Eating would fix some of that. Also, food raises dopamine level, which in turn alleviate some of the symptoms related to being "down."



If resveratrol seems to show any promise, I will start a feedback log on resveratrol during my second or third week.

what is the quercetin supposed to do?

also, what were the final thoughts about glucosamine for fat loss? i know you were experimenting/reading about it earlier

It prevents your liver from modifying resveratrol before it reaches your blood stream.

I concluded that it didn't have much effect, based primarily on

(1) strength
(2) body weight and
(3) bf measurements.

I like to base my conclusions on real measurements. Quite often I feel much better with a particular supp. And almost as often my measurements say that the supp is ineffective.

Fat loss aside...my strength has gone up since high dosing glucosamine,wasn't that the case w/you as well?

There's a couple other variables w/me though so I can't point exclusively to glucosamine as the catalyst..I did up my fish oil dosage,start on iprilflavone and Norderm concurrent w/upping my glucosamine dosage so....

Thanks for posting glucosamine experience.

I had mixed results. I was not too sure, because I was not rigid with my diet variables.

I am going to give it another go, this time, I will try to make my experiment more precise.

Let me correct the description of my "depression."

I could be imagining the whole thing, but my recent mood (which happened to coincide with resveratrol administration) seems akin to what one feels when one is faced with a difficult situation in life. It is as though some sort of mental stress handling facility has kicked in.

I feel as though everything seems so much more serious; I feel pressure. Perhaps I am confusing that pressure with depression. I also feel as though I am looking for some sort of outlet escape.

I feel alert, energized, and "desperate" as well. There is also aspect to this feeling I like.

Weird.

So .... is anyone willing to try high dose resveratrol + quercetin???

I really would love additional feedback.

Drop the quercetin for a few days and let us know if you notice a difference.

Unfortunately, I mixed the two powders and capped them. I read that, without quercetin, liver modifies resveratrol into an inactive form.

I still feel as though my mood swings are caused by resveratrol. (I never have mood swings. That is, until recently,I have started taking resveratrol).

The mood swings seem to have a pattern. I have experienced this mood swing pattern and it seems to have stages.

The first stage of the mood swing usually involves some negative-emotion generating event. It usually activates something in me that makes me restless. The overall feeling in increased insecurity and restlessness. The second stage of the mood swing is something akin to depression; it makes me view the world "seriously". The third stage comes as the seriousness turns to something like a "resolve" to do something about it. With the resolve also comes improved mood and lightness. At the fourth stage, I feel strongly motivated and become active.

So, this whole mood swing makes me feel as if I were 18-22 again, except that I am not as driven by the thoughts of sex.


The mood swings seem almost preprogrammed, designed for coping with environmental stress.

Actually,yeah I'm willing to try this but only if you can confirm that fat loss has continued on a steady basis since starting this combo.Just LMK where I can pick these 2 up at,I've been hearing BAC may be selling subpar powders so if you have a better supplier in mind hook a brotha up.

Colin:

I don't see the fat loss. In fact, fat around my waist seems to be increasing. I guess it is no go.

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Josh:

Thanks for the post. I am in the process of decreasing the dosage.

That is really interesting. Is the amount of quercetin you're taking considered a very high dose?

I am taking about 1.8 g day, divided in two doses. Don't know if it is high; I have read of people taking around 1.5 g for asthma.

I don't think quercetin is contributing to fat gain, however. From what I have read, it should help in fat loss.

Thanks Josh. I also appreciate the PM.

I suppose I should explain the background of this whole experiment.

Resveratrol (red wine extract) is the active ingredient in this experiment. I am taking it, to see if resveratrol would have beneficial effect on me. Resveratrol is supposed to activate sirt1 gene, which becomes active under calorie restriction. That's right, sirt1 gene is responsible for longevity associated with calorie restriction, and resveratrol activates that gene.

Unfortunately, taking resveratrol by itself doesn't make it bioavailable. One has to take it with quercetin, to prevent resveratrol from sulphonating. If resveratrol can bypass the liver, it may help one get leaner, as well as help one defend against the effects of aging. Resveratrol has been shown to inhibit signals that induce cell apoptosis, by activating Sirt1 gene.

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So far, I have not noticed much. I suppose, if resveratrol is to have any effect, it would be over considerable period, so I need to take it for a while.

Currently, other than my moods, I seem to be in tip-top shape. My mood swings have become much more manageable. I suppose I won't know for sure until I get my liver tested, but my feeling is that the mood swings are largely the result of resveratrol administration.

This makes sense, if you ponder that resveratrol activates Sirt1 gene. See, sirt1 gene is actually a "stress handling" gene, responsible for helping one cope with external stress (such as caloric restriction). I suspect that Sirt1 gene expression would affect one psychologically, so that one can cope with stress better. I believe my mood swings are just one manifestation of that.

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In my supp stack, I do not have anything which would heavily tax my liver. ALA, fish oil, tribulus would be it.I decreased resveratrol + quercetin dosage for a while, but currently I have returned to my original dosage.