QUOTE(virtualcyber @ Mar 17 2007, 02:46 PM) [snapback]392717[/snapback]
I am interested in epistane's ability to facilitate loss of fat with alpha receptors, "estrogenic fat", which is not pleasant to lose. ALways looking for an easier way out.
First of all, does epistane have anti-estrogenic effect, like its parent hormone? Second, if so, does anyone have a link?
I have read logs at AM about gyno reduction/removal, and, to me, it just sounds like pure b.s. Pure hype to sell epistane. It just doesn't make much sense to me.
To my knowledge, estrogen influences where you body will preferentially store fat, but it also as a whole greatly increases fat oxidation. In studies on men with exogenous estrogen, fat oxidation increased dramatically both at rest and during exercise. In women, their metabolism is most active when estrogen is at its highest during the menstrual cycle, and their metabolism is at the lowest when estrogen is lowest. From the in vitro/rat data, estrogen even causes apoptosis of adipose cells.
I could see how an anti-E could block a female fat distribution pattern for new fat stored, instead storing it probably in the gut/abdomen, but I can't see how blocking E would do anything but inhibit your ability to burn off fat that's already there. I know for a fact some of the mental benefits from AAS are due to testosterone being aromatized in the brain and sensitizing dopamine D2 receptors (which DHT cannot do as it cannot be aromatized), it wouldn't surprise me if some of the beneficial effects on body composition may also be due to aromatized estrogen's enhancement of fat oxidation. (and there are also side effects that go along with that. heh.)
Colin, regarding your gyno, is it hard tissue / enlarged nipple, or just fat? (pseudogynecomastia) I think anti-Es can only do so much if actual abnormal milk duct etc tissue is there, and that may require surgery, but there's a little literature suggesting some E blockers can do it.