The ingredient profile:

Active Ingredients (per serving):

Anabolic Primer (1.5 grams): Magnesium citrate, zinc gluconate, calcium lactate, n-acetyl-cysteine, Aminogen™

Osmo-anabolic Matrix (2.7 grams): Creatine ethyl ester, betaine hydrochloride.

Anabolic Amplification (3 grams): IP6, leucine, inositol

Note: the serving size is 2 (TWO) rounded scoops and not 3, as was misprinted on the label.


Please feel free to state any additional queries below.

how would one use this on a PSMF

ETA on the final?

As directed. Since the retail price won't be pennies, it would be advised to stick with 2 rounded scoops 3x daily. However, if desired, one may see some additional benefits dosing 2-4 extra scoops daily.



The production for the FINAL (fuck yea!) is currently underway. We are very confident in the 3-4 week timeline provided by our manufacturer.

Would there be any benefit to using an additional serving during a workout? Say, one serving pre, one serving during?

Does it work?







Just kidding.

This would be dependent on ones diet and corresponding substrate availability. As recommended, post-WO dosing is ideal for recovery and enhanced hypertrophy, due to facilitation of protein breakdown and nutrient partitioning. However, the 'Anabolic Amplification' (see listed above) does contain some ingredients that could facilitate better workouts when dosed acutely, but whether or not they are in sufficient concentration could be questioned. It does merit some experimentation, if an excess of Synthesize is in your possession, on a dosing protocol to the tune of:

Take a single serving with the following meals:
Breakfast - Pre-WO - Post-WO - Nighttime Meal

I'm torn as to which milieu (hypo/hyper caloric) would benefit greatest from this approach, unfortunitely, so I am inclined to say BOTH!

Like a fine Swiss watch plucked straight outta the display case.

Well, I have about 6 tubs of SyntheSIZE, so I could certainly give this a try. I'll dose it pre and post.

Is it me or does this stuff smell HORRIBLE!! Like a rotten egg? I just want to make sure that maybe heat during shipping didnt spoil anything? thanks

bb

FUCK yeah it works



That horrible smell you smell in it is the leucine content in it. Smell raw leucine or any EAA product with high leucine and it will more or less smell the same.

It is fine to consume but with all protein products I'd avoid having it too much in direct sunlight...and the fact that these are packaged in black containers will make it more heat prone when in the sun.

NAC smells like a homeless woman's vagina, I wouldn't count it out either.

What about splitting the dosage up more evenly - e.g. 1 scoop after every meal... Would that buy you anything?

Have you started using this Kim? And if so what dosing protocol did you use?

I've just purchased 3 tubs and am aching to get back to the gym after a 6 month absence through injury.

I've been using SyntheSIZE for at least a few months now. The dosing protocol I've settled on is 1 serving 3x a day pre-meal, and an additional dose post workout.

I do still like the idea of using 1/2 a dose 5x a day with some additional during workout. I'd probably add some additional leucine to it if I were going to do that though.

How important is the empty stomach (it says to take with meals)? I'm doing IF at the moment and don't eat until 5-7 pm... will this be a problem?

Yep.

You need to take it WITH meals. Half the point of the product is to help you utilize meals better, since food is the most anabolic substance out there.

Hmmm... so the utility during an IF protocol is halved then?

Maybe a double dose before the feast?

A double or triple dose AFTER the feast is what I've been using.

Feel free to speculate: I have added glucosamine HCl to my SyntheSIZE. If I use it during the fast, is it likely that the 'starvation genes' are turned off by invoking the fed state? The caloric value of a serving of SyntheSIZE is nil, of course, but the virtue of the product is creating the fed state without glucose intake. (Do I have that right?) Thanks!

Good point.

I read an abstract showing glucosamine to not affect leptin levels in humans... although in rats it seems to do a good job. Does it serve other purposes besides the hexosamine pathway ->leptin?

In rats, artificial sweeteners cause a release of insulin. In humans, the sight, smell, or even thought of food can do the same. As any insulin in the circulation stops the action of glucagon, epi, nor-epi, GH, etc I’m inclined to believe that syntheSIZE would be a bad idea, regardless of the effect on leptin. Might even try to avoid being around food while using an IF scheme!

I said the same thing about artificial sweeteners raising insulin, and people called bullshit becaues of lack of studies. I'm inclined to agree.
Studies?

My comment on glucosamine was an aside questioning the efficacy of adding glucosamine to your synthesize. I understand the logic of keeping it away from the fast and am doing so currently -- thanks for brining it to my attention.




I'm a waiter *sigh*. Perhaps this is a learned response, and can be unlearned by frequent stimulus without reward association? And as hypocritical as it sounds (since my last statement was total speculation), it would be great to see studies in humans showing the the magnitude of this phenomenon, and whether it's really relevant to us as IFers. In other news, I'm thinking that yohimbine should be PERFECT for an IF scheme, maybe yohimbine during the day and EC preworkout. But that's a different thread.

This is actually a pretty good point. Have we established what it is that's actually responsible for switching the "starvation genes" on or off? Is it simply lowered caloric intake, or are there other factors... insulin, mechanoreceptors, etc?

Been wondering about that myself.

Last i heard, wasn't the gene activation bit still just one of the (multiple) theories AFA IF is concerned?

It was mentioned in "Good Calories, Bad Calories" (which is a very good read by the way). I'll get the references.

Cephalic response is the term for release of insulin due to the sight or smell of food.

-------------------------------------

Friedman, M. I. "The Physiological Psychology of Hunger: A Physiological Perpective" Nov 1976 of Physiological Review

Nicolaidis, S. "Early Systematic Responses to Orogastric Stimulation" Annals of the New York Academy of Sciences May 1969

Powley "The Ventromedial Hypothalimic Syndrome, Satiety, and a Cephalic Phase Hypothesis" Physiological Review Jan 1977

Rodin, "Insulin Levels, Hunger, and Food INtake: An Example of Feedback Loops in Bodyweight regulation" Health Psychology 1985

Woods "Conditioned Insulin Secretion and Meal Feeding in Rats" Journal of Comparitive Physiology and Psychology 1977

----------------------------

Google "cephalic response and insulin" and I bet there will be more.

What type of sweetner is used in SyntheSIZE? Acesulfame K seems to stimulate insulin response:

http://www.ncbi.nlm.nih.gov/sites/entrez?c...p;dopt=Citation

http://www.ncbi.nlm.nih.gov/sites/entrez?c...p;dopt=Citation

Check out the calorie restriction studies. If there are several feedings per day, despite low calories, you can probably rule out insulin. Rat chow is something like 90% CHO; several feeding during the night would produce high insulin levels for a some time.

Sucralose and Acesulfame K.

Heh, I'm not quite sure that's applicable.

Err ... I should read beyond the title

Been using this for 5 days and it's giving me a little GI distress (the magnesium possibly?) and some urgent dashes to the bathroom. As a caveat, I did have bowel surgery back in November so that may be a contributory factor.

Thinking of dividing it into one scoop at at time rather than two to see how it fares.

Are you using the Beta or the Final?

Beta version.

Oh ok, well go ahead and try taking 1 scoop at a time and let us know if that helps. You are taking it with meals, right?

I would lower dosage as you outlined and pick up some prebiotic enzymes to improve digestion/GI health.If you have used creatine mono before with no such effect,I'd say it's almost certainly due to the recent surgery.

Gut Health from Nutraplanet would probaly be helpful.As you live in Ireland and shipping would be cost prohibitive (IMHO) for just one item,when a similiar item can be purchased locally.I think your local supermarket/pharmacy would offer a similiar product as there are many here in the US at Rite Aid/CVS/Target/Walgreens etc.

I'm using the beta so it's CEE rather than CrM. I've been taking Gut Health for a number of weeks prior to starting this aswell.

On a positive note, one scoop at a time hasn't had any adverse effects thus far.

Is synthesize no longer available from avant? I got some last year...wanted to get some more but looked inthe store and didn't see any.

It is only available to those who have Avant credit vouchers (at the Avant store).

Nutraplanet and quite a few other retailers offer it.

http://www.mindandmuscle.net/forum/index.p...mp;#entry465187

Interlink for the Avant crew for info.

I don't get it.

Dude was asking why GPA and creatine couldn't be taken simultaneously.

I don't get your not getting it.