http://www.nutraplanet.com/product/1348/sa...rrhiza-40-.html

awesome.

what's the effective daily dosage on this? 500 mg 2x daily?

Also, how easy/hard is it to cap?

Capping is pretty difficult (think Green Tea) and messy. SM gets very sticky when handled, which was the reason we are having so many problems with DCP.

Ideally, and with the great price, you would take 1.5 grams per day.

So 500mg 3xED? What's the half life of this stuff?

Also, does anyone know how long the inhibition of DGAT lasts from saliva? is it dose dependent?

Unfortunately, I am not certain this was ever ascertained. Spread out dosing would give you decent inhibition all day long.

I would love to see some feedback on mega dosing, honestly, especially at this price. I think I will have some sent out to me to try this out

Dsade, 3x throughout the day but...

before meals?
during meals?
after meals?

or does it not matter?

For DCP, I recommend taking it 1/2 hour before meals...I would recommend the same with Bulk SM.

I'm assuming this would stain like a motherfucker, but wouldn't it possibly be useful in a local topical carrier? Or does salvia work most of its magic in the liver?

A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza.

The nature of intestinal absorption of most herbal medicine is unknown. Cryptotanshinone (CTS) is the principal active constituent of the widely used cardiovascular herb Salvia miltiorrhiza (Danshen). We investigated the oral bioavailability of CTS in rats and the mechanism for its intestinal absorption using several in vitro and in vivo models: 1) Caco-2 cell monolayers; 2) monolayers of MDCKII cells overexpressing P-glycoprotein (PgP); and 3) single-pass rat intestinal perfusion with mesenteric vein cannulation. The systemic bioavailabilities of CTS after oral and intraperitoneal administration at 100 mg/kg were 2.05 and 10.60%, respectively. In the perfused rat intestinal model, permeability coefficients based on CTS disappearance from the luminal perfusate (Plumen) were 6.7- to 10.3-fold higher than permeability coefficients based on drug appearance in venous blood (Pblood). Pblood significantly increased in the presence of the P-gP inhibitor, verapamil. CTS transport across Caco-2 monolayers was pH-, temperature- and ATP-dependent. The transport from the apical (AP) to the basolateral (BL) side was 3- to 9-fold lower than that from the BL to the AP side. Inclusion of verapamil (50 microM) in both AP and BL sides abolished the polarized CTS transport across Caco-2 cells. Moreover, CTS was significantly more permeable in the BL to AP than in the AP to BL direction in MDCKII and MDR1-MDCKII cells. The permeability coefficients in the BL to AP direction were significantly higher in MDCKII cells overexpressing PgP. These findings indicate that CTS is a substrate for PgP that can pump CTS into the luminal side.

PMID: 16497784 [PubMed - indexed for MEDLINE]

Pharmacokinetics, tissue distribution, metabolism, and excretion of depside salts from Salvia miltiorrhiza in rats.

* Li X,
* Yu C,
* Lu Y,
* Gu Y,
* Lu J,
* Xu W,
* Xuan L,
* Wang Y.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Salviae miltiorrhiza, a traditional Chinese medical herb known as "Danshen," has been widely used in clinics to improve blood circulation, relieve blood stasis, and treat coronary heart disease. Depside salts from S. miltiorrhiza are a novel drug in which magnesium lithospermate B and its analogs are the active components. The pharmacokinetics, tissue distribution, metabolism, and excretion of three of the major components, lithospermic acid B, rosmarinic acid (RA), and lithospermic acid (LA), were studied by liquid chromatography-tandem mass spectrometry following intravenous administration in Sprague-Dawley rats. The elimination half-lives for LSB, RA, and LA were 1.04, 0.75, and 2.0 h, respectively, when 60 mg/kg S. miltiorrhiza depside salts were administrated. The areas under the curve for LSB, RA, and LA were 51.6, 6.6, and 25.2 mg . h/l, respectively, and the values decreased in the individual tissues in the following order: kidney > lung > liver > heart > spleen > brain for LSB; kidney > lung > heart > liver > spleen > brain for RA; and heart > lung > kidney > liver > spleen > brain for LA. After intravenous administration of 60 mg/kg S. miltiorrhiza depside salts, 86% of the LSB was excreted in the bile within 6 h. The main metabolites M1 and M2 were found in the serum. Overall, the results show that depside salts from S. miltiorrhiza are rapidly and widely distributed to tissues after intravenous administration in rats but that they are also rapidly cleared and excreted.

PMID: 17132761 [PubMed - indexed for MEDLINE]

Now all we need is Bulk GPA so we can have bulk phenogen.... (or GPA + DCP which would kick some major ass I'm sure).

finally!!!

We did it all for the Nookie...and for you, Liorrh.

Did you end up trying this?

Not yet, no...soon.

What are the odds looking like on availability of a capped version?

I'll probably be "mega-dosing" for a week when I go on vacation at the end of this month.

Odds are pretty long. Launch of a new SKU takes quite a bit of capital, and doubtful this would sell good enough to justify a $5k investment.

I ordered some.... 75grams.. not sure how ill take it yet, cos i have a mean stack of supps on me atm.... LOL..

megadosing SM is useless. its been asked before, do a search

capped some today. Easy to cap, ~250 mg fits perfectly into 1 cap without having to tamp it at all

Did you cap the whole container in one sitting? 250mg per cap is definitely useful. It tamps readily, so you should be able to get 500mg into a capped 00.

nah, didn't get around to doing it, i was just seeing if I could get away with my lazy method of 1/4 tsp scraped into 2 caps and it worked.

How is the rest of the jar surviving? Salvia at this concentration gets extremely sticky when exposed to air and/or moisture.

Has anybody tried SM while bulking? Seems like it could fit nicely into a lean bulk.

the rest of the salvia seems to be just fine. smells like funky rhodalia though. I guess i'll try to get the rest of this capped tomorrow if there is a risk of losing some to stickiness.

thanks for the heads up

My pleasure. I got to work with this stuff when we first got it in fort Phenogen, and I had left the lid off for about an hour. When I came back, it had started getting a sticky, oxidized "skin" that was pretty messy to remove. Quite a bit lost to waste that I don't want to see others suffer.

Also found out this
SM is anti cox-2 activity but not expression, anti ANG, boosts acetylcholine, protects from stroke damage inhibits JNK and TNF

that's the thing about plants, they have alot of effects all this is good moderately, but bad in excess

that is why you never megedose extracts.

Bumpity