Maybe L-Theanine, Bacopa and Ashwaganda? Your PEA/Hordinine caps are quite a hit with me and my friends

Good call. Something like 200mg theanine, 100mg bacopa, and 500mg ashwagandha? I don't remember good doses of any of those, but I think those are close to what is recommended and could fit in 1 '00' cap.

I'd buy it

Throw in some Phenibut and Magnolia Extract and I would throw my name behind it for sure.

I don't know about magnolia, but don't include phenibut. Tolerance develops. Pointless addition after the first few days of dosing.

As much as I like phenibut....I agree with Jeff but you could add either inositol or taurine

I vote against the taurine, as it can give me the poops. Otherwise it's a valuable nutrient. Inositol would be a decent addition too, as the filler.

Lower dose taurine should be fine without giving you the runs...Inositol is an excellent call. Maybe if I can nail that SAMe finally...

i don't see myself purchasing this product

but.. i think 100 mg picamilon would be a nice addition to said ingredients

Define "lower taurine dose."

I've taken up to 10g without any shittiness.

I don't see how SAM-e could be incorporated into this,considering how unstable it is.

I agree phenibut would be a deal killer,I think corriander would serve as a decent replacement and it would be much cheaper to source than picamilon I'd think.

Let's quit trying to make it more fancy. Theanine, inositol, bacopa, ashwagandha, and a low dose taurine. Perfect. If you keep adding junk, you'll just end up with another product Psychotropin or whatever. Just keep it simple and effective in the correct dosages.

Coriander would have to be made into a concentrated extract...which can be done, but not quickly. Otherwise dosage would be too high.

Exactly. So stick with my idea

1: Eur J Pharmacol. 2007 Jul 4; [Epub ahead of print]
Behavioral effects of the beta(3) adrenoceptor agonist SR58611A: Is it the putative prototype of a new class of antidepressant/anxiolytic drugs?
Consoli D, Leggio GM, Mazzola C, Micale V, Drago F.

A large body of evidence corroborates the notion that deficiencies of serotonergic system are likely involved in the pathogenesis of both depression and anxiety. Activation of beta(3) adrenoceptors has been shown to increase brain tryptophan content suggesting an elevation of brain serotonin (5HT) synthesis. SR58611A is a selective beta(3) adrenergic agent possessing a profile of antidepressant activity in routine rodents' experimental models of depression. The present study was undertaken to evaluate in rodents the antidepressant properties of SR58611A and to assess its putative anxiolytic value in experimental models of depression and anxiety. Compared to the control group, SR58611A (0.1, 1, 5 or 10 mg/kg) caused a dose-dependent reduction in immobility of Wistar male rats in the forced swim test. The maximum dose appeared to be equivalent to an effective dose of clomipramine (50 mg/kg). In addition, acute injection of SR58611A induced in rats a dose-dependent decrease in grooming response to a novel environment (novelty-induced grooming test). For any dose, the effect was lower than that of diazepam (1 mg/kg). Chronic treatment with SR58611A resulted also in an increased social interaction time in the social interaction test without affecting motor activity of rats. Furthermore, similarly to diazepam a chronic treatment with the highest doses of SR58611A was followed by increased exploratory behavior in Swiss male mice exposed to the elevated plus maze test. These effects are mediated by beta(3) adrenoceptors since i.p. pretreatment with the selective beta(3) adrenoceptor antagonist SR59230A (5 mg/kg) blocked the effects of SR58611A. Finally, also the 5HT antagonist methysergide (2 mg/kg) prevented the antidepressant and anxiolytic-like activity of SR58611A indicating that 5HT transmission is strictly involved in its action.

PMID: 17669397 [PubMed - as supplied by publisher]


Anyone ever notice any anxiolytic effects from Octopamine?

Need this product, schools coming, and summer is my splurge time of year.

Update?

Bump for an update D!

I think inositol is a pointless addition. IME it's only useful in the 5-10 GRAM range. Not well-suited for a capsule product. Either you take a hit on your bottom line or you hit the customer's wallet, all for the sake of having one more thing on the label and negligible added effect. Also I think that SAMe would be a poor addition, even if you could get it stable, as it can exacerbate certain states of excitation. Otherwise, I like it.