Anyone? Just curious about personal experience.

This is the same active compound as Xenical, which has been out since forever. Just a FYI.-

And the side effect profile alone would keep me far away from either.

The interesting thing is that it causes problems for a lot of people when they eat high fat diets (IE explosive uncontrollable diarrhea), thereby for people to use it successfully they must lower their fat intake (and probably total caloric intake) significantly. This or invest heavily in Depends.

I have often wondered about drugs which use this or similar mechanisms, attacking obesity by forcing people to change habits. I haven't tried it yet,but I have found prop glycol makes me uninterested in eating because it numbs my tongue enough. Then eating becomes laborsome and unrewarding.

Only ten percent of xenical users got a second prescription filled.
Alli is just a lower dosed xenical obviously... And there is a study showing where a group lost only three more pounds of fat than a placebo group when using xenical... I forget if it was six months or a year. They were both excercising.

I really don't like how this stuff is being sold in GNCs and the like.

This is the idea behind gastric bypass surgery....forced portion control...which basically tells me that obesity is a lack of ability to control one's eating more than anything else.

I will agree, although there are other additional aspects, obviously.

Thus far I've personally had 4 patients in clinic who began taking Alli (not on my recommendation) and only 1 has enjoyed the experience enough to ask for a prescription for full dose Orlistat.

Since Alli is basically underdosed and overpriced, the efficacy per dollar spent is minimal and the only real sense I could see in anyone using it would be if they were going to have a super high fat cheat meal and didn't mind spending the next 3-4 hours on the toilet.

For the patient who tolerates it alright, the efficacy is low anyhow and unless they are modifying lifestyle (diet/exercise) the effects are transient.

All in all, cheers to the manufacturer, they'll surely make a few bucks.

Apparently the prescription strength stuff blocks 25%-30% of ingested fat from being processed. Sitting on the toilet for 3 hours shitting fat out of my ass just doesn't seem like an enjoyable experience...

seems more or less like Anabuse for fat. Except it wont kill you. Just make your ass explode. Actually, it's very interesting. I wonder if in the future - high speculative here - that obese children could be court ordered to take this shit to lose weight. Super concentrated doses of coarse. This would be after we cane the parents like in Singapore.... god I love that country.

Same thing happens when I drink beer basically. Might as well be losing weight from the whole thing

I dunno... beer shits are bad enough. Beer + orlistat shits? Eesh...

Reminds me of this one time when I ate an entire party sized bag of WOW! chips, the ones cooked with Olestra. Big mistake.

The answer is no.

Oddly, when we prescribe orlistat to people, we do recommend that they carry a change of underwear with them "just in case." No lie.