And oh what a sweet price it is...100 grams only $5? 500 for only $15? A Kool Kickass Kilo only $25?

Don't let carb restriction and low cal short circuit your metabolic fat burning/muscle building signals.

Looking for feedback here combined with SyntheSIZE.

http://www.nutraplanet.com/product/nutrapl...-100-grams.html

http://www.nutraplanet.com/product/nutrapl...-500-grams.html

http://www.nutraplanet.com/product/nutrapl...der-1-kilo.html

The combination of glucosamine and SyntheSIZE works pretty FUCKING AMAZINGLY WELL

I kept a 2 month log on this stack,supplementing 2g glucosamine hcl w/each SyntheSIZE dose:

http://www.mindandmuscle.net/forum/index.p...p;hl=synthesize

Does a kilo purchase come with the fabled supplemental glucosamine t-shirt you made?

Would a used Kleenex work for you?

Isn't there a study showing glucosamine to have no significant effect on leptin levels in humans?

Thanks to NP for an awesome price for a great product for joint support, but has this been refuted WRT leptin levels? And wouldn't Avant have left it in if it had?


Hmmm... full text?

Title: Effect of oral glucosamine sulfate on serum leptin levels in human subjects.
Source: Nutrition (Burbank, Los Angeles County, Calif.) (Nutrition) 2004 Mar; 20(3): 321-2
Additional Info: United States
Standard No: ISSN: 0899-9007 (Print); NLM Unique Journal Identifier: 8802712
Language: English

It's a research letter (not the greatest, either) claiming not a lot happening at 3g or 6g.

Can anyone who has access to any of those sites that have this study,please post the full study here?


Par has proven (via his referenced leptin articles) contrary,to the hilt,to what this study may suggest.

All of the studies I have read point in favor of using Glucosamine, as well as quite a bit of personal experimentation.

I agree that anecdote seems overwhelmingly positive.

Isn't the bulk of the research showing positive results done in rats? That's why this human study shocked me.

Why would avant pull it from synthesize if it works so well?

I think the bulk of the studies done were on rats,not sure though.This is true of a LOT of compounds though and the human "study" above is a research letter

I think it was pulled from SyntheSIZE because higher glucosamine intake is moot and not desirable for most,when in a caloric surplus.That group likely represents the bulk of people who would buy SyntheSIZE.Hiogher dosage of glucosamine,unl;ess you're particularly ecto to meso,will make you fatter than your set point,if you're an endo who's bulking so that's another variable.

Par posted(way back when the beta was issued) that SyntheSIZE with 6-10 grams (I vividly remember those figures) of glucosamine per day would render Leptigen Mass like effect,when in a very slight surplus.He may have said it would've done this at at maintainance kcals too,I can't recall.

At any rate,this is just my guess as I'm in over my head in assuming calls made by Avant so I'll get Savage to weigh in on this.

I haven't heard of this before. What's the deal here?

It's been a couple of years so I'm hazy on the details but Spook was the one to bring this to light.I do remember that he said this could be negated via sesamin supplementation,to what extent I'm not sure.I'll try to dig up Spook's posts on this.

If you're fat you wouldn't want glucosamine because you already have high circulating levels of leptin. In this case you'd want to improve leptin sensitivity, not output.

If Colin is referencing the insulin resistance issue, I've yet to see it produced in humans by oral doses.

Post # 16 by Spook,taken from the thread below.



just a word of caution. Endo's need to be carefull with glucosamine.

I discussed this ages ago. I think it was at the very end of the vinegar thread.

the same way glucosamine increases leptin it also can increase insulin resistance in skeletal muscle. Normally this is not a problem. I outlined in that thread that HBP flux is normally not an issue ans in healthy normal people UDP-Glac-* compunds are metablized away quickly. In diabetic tissue sample though the problem is not that they make to much UDP-Glanc-* compunds its that they don't break them down. This build up results in insulin insensitivity. thus endo's need to be mindfull as they are the group that is most likely to expirience this downside of high doses of glucosamine.

Its still unknown why certain people are prone to this. To combat this I would recomend you use sesathin along with high dose glucosamine if you are so inclined as to try this expiriment as an endomorph.



http://www.mindandmuscle.net/forum/index.p...t=0&start=0

I agree with this but fat is a vague term and one also has to account for lowered leptin levels in the overweight due to extended periods of dieting.

I was lean but still carried a signifigant amount of fat when I used glucosamine + SS last (12-15%) and I'm an endo with a set point around 20%,it certainly worked nicely in my case.I used Sesathin at normal dosages,no fibrates or anything else esoteric while on the SS/G HCL stack.I got to roughly 12% by the end of the 60 day period,had I continued on another month (at 1500-2000 kcals e/d) I would have gotten a 6 pack and burnt off my pseudo-gyno completely.I also hit several PR's and strength went up across the board,and this was in a large caloric deficit while running putting in at least 10 miles per week of cardio,via running and HITT,per week.That said,my anecdotal feedback shows that the THE SHIT WORKS BROS!!!!111111!!!!!

I think this is similar to my case. I would say I'm more endo than anything, but just have gone through extreme protocols to get to my lower BF% now (PSMF, UD2, etc)..

I'll have to try this out as I'm at the point where I can NOT get my BF% any lower without killing myself (had a heart arythmia, due to over-doing UD2 version)..

Thoughts?

I think it's certainly worth a try. It's not like glucosamine is that expensive.

This was kind of the point. After months and months of requests, I finally hit the right supplier with the right price and BAM.

I'm all over this stuff and SyntheSIZE.

It was not pulled from SyntheSIZE -- it was never, ever going to be in it.

We dropped the Leptigen line was because it was just too complicated for the people to get.

We dropped the whole "leptin" angle. SyntheSIZE is like LG Mass without the leptin angle. Glucosamine is part of the leptin angle.

Right, poor choice of wording OMP.

Too complicated? How is this? Even if people don't understand the science, if the product works well (and leptigen seemed to be a hit -- I'm sorry that it was "before my time") they will see results.

But if people don't understand what a product is even supposed to do, they're less likely to ever give it a try.

Not necessarily, people merely need to know what the product is intended to do, not how. Companies often use verbose wording into convincing consumers that the product is well formulated.