I received the goods from CNW today and dosed 150mg (actual powder,not fuc content) a couple hours ago.

I'll post relevant stats after weighing myself tonight at my gym and I'll take some pics tonight as well.

I've been switching from below maintainance and well above maintainance basically on a whim,for some time now.As of today I am leaning towards the idea of starting out around 2000kcals(a deficit of around 500 for me) for the next month and after acclimating myself to lowered kcals,starting on an IF type diet or an extended PMSF.

For appetite supression I'm primarily hitting up the CB1 angle via low dose cayyene,higher dose SEA and Rimbonant at 5mg.The former two may be dropped altogether if i the side effects of rimbonant aren't too pronounced as I ramp up dosage.Note that these 3 compounds have no impact on actual FFA oxidation(save the cayenne but the low dose I'm using will do fuck all for fat loss,only apppetite supression if my theory is correct) so I don't consider them to be signifigant variables at all.

Supplementation for this trial will not have changed in any other form besides the addition of the aforementioned three compounds.For the past 7-8 months I've been using beta alanine,citrilline malate,ALCAR,piracetame,aniracetame,moderate dose epa/dha and choline and this is not changing.

Temperature readings will be taken regularly (at an established time before cayyenne dosing) and fuc will be dosed at 15mg of the active thrice daily on an empty stomach.

Looks groovy. You've inspired me to trial some cayenne, and start up on some pira again.

Are you going to do 150mg x 3 a day?

Yes,focoxathin will be dosed 3x per day between meals.

I'm not sure what you mean with the cayenne comment,this is specifically why I'm using it in conjunction with SEA+rimbonant:

Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells.
Maccarrone M, Pauselli R, Di Rienzo M, Finazzi-Agrò A.

Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy. Maccarrone@med.uniroma2.it

Stearoylethanolamide (SEA) is present in human, rat and mouse brain in amounts comparable with those of the endocannabinoid anandamide (arachidonoylethanolamide; AEA). Yet, the biological activity of SEA has never been investigated. We synthesized unlabelled and radiolabelled SEA to investigate its binding, degradation and biological activity in rat C6 glioma cells. We report that SEA binds to a specific site distinct from known cannabinoid or vanilloid receptors, and that AEA and capsazepine partly (approx. 50%) antagonized this binding. Treatment of C6 cells with SEA inhibits cellular nitric oxide synthase and does not affect adenylate cyclase, whereas treatment with cannabinoid type 1 agonist 2-arachidonoylglycerol activates the former enzyme and inhibits the latter. C6 cells also have a specific SEA membrane transporter, which is inhibited by NO, and a fatty acid amide hydrolase capable of cleaving SEA. In these cells, SEA shows pro-apoptotic activity, due to elevation of intracellular calcium, activation of the arachidonate cascade and mitochondrial uncoupling. NO further enhances SEA-induced apoptosis. Moreover, the cannabinoid type 1 receptor-mediated decrease in cAMP induced by AEA in C6 cells is potentiated by SEA, suggesting that this compound also has an 'entourage' effect. Taken together, this study shows that SEA is an endocannabinoid-like compound which binds to and is transported by new components of the endocannabinoid system. It seems noteworthy that degradation and pro-apoptotic activity of SEA are regulated by NO in a way opposite to that reported for AEA.

PMID: 12010121 [PubMed - indexed for MEDLINE]

What is the best way you have found to use the SEA? With or apart from meals? Before or after. Whenever I use it I get hungrier.

From what I've read on SEA it seems that it should be taken apart from meals.

When injected into the abdomen of a mouse,the anorexic effect is evident after 2 hours.That said,I would think that when taken orally,it's best to take immediately upon waking with a large glass of water while staving off any food intake for at least 1/2 an hour.AFAIK there is no literature on SEA's anorexic effect in humans my extrapolation/guess is likely the best method.

I don't see why SEA would make you hungrier.

Fuck,I am stupid.

Reading the study above I now see that cap (my roundabout source of cap being cayenne) ANTAGONIZED the binding so.....I am dropping cayenne from this trial.

Body temp,taken via oral thermometer,was 99 upon waking today.For refererance,it was 98 last week upon waking.

I haven't been feeling any sort of hot flashes a'la DNP nor any discernable rise in body temp thoughout the day.

Weight is 198,several hours after waking,checked on an empty stomach.

I took some pics with my cell earlier today and will post them up,along with post-trial pics,when I end this fuc trial.

Interesting WRT body temp... what is it normally?

Well I checked it last week and it was 98 to 98.5,I've got an old school thermometer so I can't give an *exact* reading.That is the baseline I'll be going with.

I have been feeling a bit flustered since lifting earlier this evening,I take this as a subtle indication of some uncoupling action as I'm not usually prone to excessive body heat for so long after training.The only caffiene I took in today was a dose of Scorch pre w/o,around 8 hours ago and as I'm only dosing sesa sparingly (acutely for social/holiday reasons) and took none today I see no other reason for the heat.

Weight is up a whopping 5 pounds this morning due to holiday excess,I'll extend the trial another week to displace this past one as (largely) for all intents and purposes the point of this trial was to observe fat loss while in caloric deficit whilst on fucoxathinn.Although,anti-fat gain while eating in a asurplus seems to be somewhat possible with this,as I noticed a marked rise in body temperature directly after ingestion pf ample carbs,as I've seen while on DNP.Body temp rise was enough to produce a very faint amount of sweat,opposed to profusive sweating a'la DNP but uncoupling is undoubtly still present.

Hell,I bought two bottles from CNW so i could extend this for several more months than planned but I'll decide on that after the 5 week period is done and a one week wash out is taken.I'll experiment with a fat based delivery system the next time around,capping has been how I've been going about getting it in me so far as a whiff of the powder made me retch.

taste is bad... I need a capping machine pronto

There is no way I would take this shit without capping it,on a regular basis.

How are you dosing it?
Just eyeballing it and parachuting it in some diet soda/whatever?

Apparently fat may be the optimal way to dose this but carrying around fish oil,olive oil is problematic and calorically prohibitive.That is,if you're not on a high fat diet as that's around 50 grams of fat per day.

I'd suggest buying the smallest gelcaps that Now offers and fill it up to give you the desired amount,I can eyeball 150mg (margin of error 10%) easily with this method.

Agreed, are you still doing 150mgs 3x a day?

Yes,will continue on at this figure for at least 4 more weeks,the remainder of the time being in a deficit of at least 500.

I haven't updated in a few days because no fat loss has taken place IE I've been in a surplus due to Christmas/family gatherings etc.

I usually use water, but diet would be a much better choice. I try to make it a swift process. The problem is the part of your tongue that tastes this awful shit is in the back so your guarenteed a sour look on your face at least for a couple seconds.

I have also been using the eyeball method, and dose mine with fish oil. I'm actually back on track with the diet and when I do - I usually keep fats around 35-55grams with 12-16 coming from fish oil. I use gel caps so I just put them in a baggy to dose.

Anyone who has been using this stuff: are you noticing less appetite? Are you eating less food without really trying or do you have to strain to keep on a diet? That is where the rubber meets the road.

No reduction in appetite at all,I wasn't expecting anything along these lines either.

IOW,this compound doesn't make dieting suck less but the literature suggests it will make the process more efficient.

I haven't noticed any suppressed appetite either.

caps would be better yes?

Absolutely.

Yeah,I second this motion.

I've already got two bottles though (and usually prefer to buy in bulk b/c caps are on average upwards of twice the cost for the same amount of product) but fucoxathin smells unusually bad and is a pain in the balls to cap e.g.very sticky.

I mixed it 50-50 with resveratrol and capped it very easily.

Well,I am certainly seeing more of a propensity towards a rise in body temp from this,mild aerobic activity such as warming up pre-lifting,will have me flushed with heat and induce a light sweat.

Body temp has been consistent at 99 ED,taken upon rising.

do you notice a concurrent increase in breathing rate?

I'm a smoker so this is hard to account.That said,I'd say breathing rate is increased during this time period,allowing for the fact my wind capacity is lowered as it is.

Well,as of pushing 3 weeks on this I can say that there is a definite rise in body temperature throughout the day.

Fat loss was shafted as a couple days after starting on fucoxathin i started eating in a heft surplus for about over a week and gained a decent chunk of fat.I am always amazed at just how quickly I can gain fat while in a surplus but in this case as I wasn't training regularly due to a wrist injury.I'm not into the mentality of doing traditional cardio right now as I naturally loathe running and my style of training is virtually aerobic weight lifting so running on a treadmill is much less enticing post w/o.

Meh,so I put in ONE cardio session (and did a LOADS of squats 2-3 days per week) since starting during the partial lay.

That stated,as i took pics pre trial and actually look worse (hehe,as opposed to better) NOW due to the excessive fat gain I'm not all that sure my post pics will be of any signifigance.Well,weight loss is holding steady at 2 pounds per week (since the initial screw up at the start of the log) and I intend to go another two weeks on this.

20mg Rimbonant and 300mg WellbutrinXL( added last week to mitigate rimbonant's sides among other positive effects) is pretty damn potent WRT appetite supression as I've been taking in 10 kcals per pound b/w with little trouble.IOW,I expect to lose another 5-6 pounds while on fucoxathin.

Are you assessing body temp with a thermometer or just gauging how you "feel"?

I've been taking body temp every day upon rising and it is consistently at one degree higher than it was when I took it several days before I started using fucoxathin for the sake of comparison.

As stated earlier,I am also sweating "easier" as far as after 15 minytes of intense lifting w/minimal rest intervals I'm thoroughly drenched.i sweat heavily as it is but this is kicking it up a solid notch.

No antiperspirants for you I see!

I'm not sure I get the joke,if this is one.


Well,I weighed in at 192 over the weekend and 192 earlier today,lower than I had thought.These weights were taken with professional scales and as it turns out,the scale I used to gauge weight to start out this trial with is inaccurate.I weighed 198 by the scale (rusty thing in my basement) that I weighed myself with at the start of the trial.

I weighed 205 after I gained weight due to holiday related eating so from the start of this trial til now this is what I am looking at:

Start:192
7days in after binges:199
Now:192

I'll continue on another week at this dosage.

Kcals have ranged from 1800-3000 averaging at 2000 (a very modest deficit for me w/my current acivity level) since after the 7 day binge.

It appears as though dosage should be higher to induce a signifigant uncoupling effect.

A friend of mine is dosing 250mg (Active Fuco) three times per day. He has just started, be interesting to see how he gets on at such a high dose.

How is your appetite?

Fuco hasn't effected my appetite at all.

I started on rimbonanta bitafter fuco and that supresses it to a signifigant degree.

Fat loss has stalled this week,only one pound has been lost.

FYI

I think this has been posted here before:

Dietary Combination of Fucoxanthin and Fish Oil Attenuates the Weight Gain of White Adipose Tissue and Decreases Blood Glucose in Obese/Diabetic KK-Ay Mice

Abstract:

Fucoxanthin is a marine carotenoid found in edible brown seaweeds. We previously reported that dietary fucoxanthin attenuates the weight gain of white adipose tissue (WAT) of diabetic/obese KK-Ay mice. In this study, to evaluate the antiobesity and antidiabetic effects of fucoxanthin and fish oil, we investigated the effect on the WAT weight, blood glucose, and insulin levels of KK-Ay mice. Furthermore, the expression level of uncoupling protein 1 (UCP1) and adipokine mRNA in WAT were measured. After 4 weeks of feeding, 0.2% fucoxanthin in the diet markedly attenuated the gain of WAT weight in KK-Ay mice with increasing UCP1 expression compared with the control mice. The WAT weight of the mice fed 0.1% fucoxanthin and 6.9% fish oil was also significantly lower than that of the mice fed fucoxanthin alone. In addition, 0.2% fucoxanthin markedly decreased the blood glucose and plasma insulin concentrations in KK-Ay mice. The mice fed with the combination diet of 0.1% fucoxanthin and fish oil also showed improvements similar to that of 0.2% fucoxanthin. Leptin and tumor necrosis factor (TNFα) mRNA expression in WAT were significantly down-regulated by 0.2% fucoxanthin. These results suggest that dietary fucoxanthin decreases the blood glucose and plasma insulin concentration of KK-Ay along with down-regulating TNFα mRNA. In addition, the combination of fucoxanthin and fish oil is more effective for attenuating the weight gain of WAT than feeding with fucoxanthin alone.

Thanks for the study,Lliorh.

Fat loss this week was also one pound,just as it was last week.

I do supplement with a at least 2 grams epa/dha ED but that means little if the bioavailability of fuco is so low.

Judging by the rate of fat loss over the past month in comparison to the deficit I have had in place I'm not really impressed.Fuco was marginally effective WRT facilitating fat loss at best,with a dosing protocol of 150mg thrice daily between meals.

If a higher dose was used in combination with a spoonful of fish oil (perhaps just a double dose of Sesathin would suffice) timed to coincide w/each dosage,I think this may be an effective approach.

How about a waist measurement? Fucoxanthin should preferentially reduce visceral fat.

Interesting study Liorrh posted. So if that's true, one would have to use a fairly high does of fucoxanthin, that or administer it through some other route other than oral.

I didn't take waist measurements beforehand as I wasn't aware that fuco primarily mediated VAT (if this is indeed the case)so a waist number now wouldn't determine anything.

I don't have a particularly large issue with VAT anyway,that is relegated to more of an ecto phenotype and I'm the opposite.

Oral is the only way to go theoretically,even if it worked transdermally the smell of the powder is distinctly unpleasant.

Some of the research shows improved insulin sensitivity. It has also been speculated by the researchers.

Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues.Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K.
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.

Mitochondrial uncoupling protein 1 (UCP1) is usually expressed only in brown adipose tissue (BAT) and a key molecule for metabolic thermogenesis to avoid an excess of fat accumulation. However, there is little BAT in adult humans. Therefore, UCP1 expression in tissues other than BAT is expected to reduce abdominal fat. Here, we show reduction of abdominal white adipose tissue (WAT) weights in rats and mice by feeding lipids from edible seaweed, Undaria pinnatifida. Clear signals of UCP1 protein and mRNA were detected in WAT of mice fed the Undaria lipids, although there is little expression of UCP1 in WAT of mice fed control diet. The Undaria lipids mainly consisted of glycolipids and seaweed carotenoid, fucoxanthin. In the fucoxanthin-fed mice, WAT weight significantly decreased and UCP1 was clearly expressed in the WAT, while there was no difference in WAT weight and little expression of UCP1 in the glycolipids-fed mice. This result indicates that fucoxanthin upregulates the expression of UCP1 in WAT, which may contribute to reducing WAT weight.

PMID: 15896707 [PubMed - indexed for MEDLINE]

Alright but there is still the issue of low bioavailability.

I don't know if this would be cost prohibitive if dosed at the amounts needed for its effect on UCP1 and for that matter,proper dosing in humans has yet to been established.I can say with certainty that 150mg 3xED does not suffice,as far as an uncoupling agent is concerned.

If there is interest I will report how my friend gets along on his dose of 250mg (Active Fuco) three times per day.

If by "Active Fuco" you mean the actual content of fucoxathin he's taking per day?

If so,I would really like to see how he fares and I'm sure other would as well.

That is more than ten times the amount that I took,for a month.

Do you think he'd consider keeping a log here on his usage?

Yes, he is taking 3 * 500mg caps per day of 50% Fucoxanthin.

Now two weeks in and he is reporting lots of heat and a little lethargy.

Unfortunatley he is bulking, but has said he seems to be staying lean even with the calorie excess. He controls his diet well and has competed previously.

He makes comments in his online journal. Not a log as such.

I will report his observations.

Can you give a link to his journal?

Also,please post where he's buying the 50% fuco from.

Add MCT oil, it will work wonders

Z

What will the MCT oil do?

It will increase absorption.

Z