http://www.mindandmuscle.net/forum/index.p...mp;#entry443752

Think you guys can source some bulk quality celery seed extract?

What do you want that for? BP?

We're looking at doing a good BP reducing supplement. Looks like high potency is the way to go.

Shouldn't be too expensive.

I bumped him for this at AM

edit: there ya go!

Time frame?

Benson: Yes. But the other benefits are welcomed as well.

Unknown...we have a lot on the plate right now with new product releases.

Many other benefits

Somewhere I read that the MOA was that of a Ca-Chanel blocker which is not so good for you. I'd suggest pomegrante juice...as little as 50ml a day shows clinical reductions in BP and is otherwise all sorts of good for you, also a baby aspirin taken at bedtime will help.

Source suggestion for the pomegrante juice?

Local grocery store juice aisle. Look for Langers brand 100% juice.

http://www.lef.org/protocols/heart_circula...pressure_01.htm

Pomegranate extract. Pomegranates are fast becoming known as one of the healthiest foods we can eat, largely because of their beneficial effects on cardiovascular health (Aviram M et al 2001). While many people drink pomegranate juice, pomegranate extract may hold even greater benefits.

The benefit of supplementing with pomegranate extract (rather than drinking the juice or eating the fruit) is that the extract, unlike the juice, contains virtually no sugar or calories, and requires no refrigeration to maintain optimal quality. Interestingly, commercial pomegranate juice and whole fruit extracts contain beneficial phytonutrients that are not obtained from eating the pomegranate fruit itself (Gil MI et al 2000). In particular, punicalagins, the primary antioxidant found in pomegranates, are concentrated in the husk and in the juice of the whole fruit (Gil MI et al 2000).

While some pomegranate products are standardized to contain high levels of ellagic acid (an antioxidant and phytonutrient that has anticancer potential), focusing on ellagic acid alone is unlikely to provide optimal synergy among the phytonutrients found within pomegranates (Lansky EP 2006). Emerging research suggests that products standardized in punicalagins confer the greatest benefit by providing the highest levels of pomegranate antioxidants.

Scientists are now studying pomegranate extract to uncover the many advantages it may have for human health. Pomegranates contain an array of beneficial phytonutrients such as phenolic compounds and tannins, including punicalagins, which are unique to pomegranates. Several compounds in pomegranates are potent antioxidants and ACE inhibitors (Aviram M et al 2001). Researchers have determined that oxidative stress can disrupt the balance of vasoconstricting and vasodilating biochemicals in the endothelium, contributing to high blood pressure and endothelial dysfunction. By quenching oxidative stress, antioxidants may help prevent vasoconstriction, lower blood pressure, and promote healthy endothelial function (Kitiyakara C et al 1998). Scientists believe that pomegranates, a potent source of antioxidants, may promote healthy blood pressure levels by enhancing the activity and preventing the degradation of an important vasodilating agent. These benefits may also lead to improvements in endothelial function (Ignarro LJ et al 2006).

EDIT: I am also finding research that suggests that a bit higher dose of the extract is good for prostate health.

http://customnutritionwarehouse.com/pomegr...ree-p-1403.html

I've noticed that the problem with CNW's caps is they don't state the standardized extract. This was a big concern with the hawthorn berry I was using from them...I was taking 3.3g to no avail, then switched to a potent standardized extract and saw the results turn fast.

I was going to pose that question about their powder as well.

HerbalCom has 1 lb of celery seed powder for only $2.95. Its no extract, but a pound for less than $3?
This is a new discovery of mine and I have no idea about the reliablity of the company or products. They do offer free shipping in CONUS. Cheap-ass prices for bulk herbs.

Problem with whole herb is that the majority of the weight comes in the form of cellulose (vegetable fiber). While beneficial in its own right, you are looking for a standardized extraction of actives - get your fiber elsewhere.

Any word on this?

Cardiovascular pharmacology of 3-n -butylphthalide in spontaneously hypertensive rats
D. Tsi, B. K. H. Tan *
Department of Pharmacology, Faculty of Medicine, Lower Kent Ridge Road, National University of Singapore, Singapore 119260

Abstract
The hypotensive and vasorelaxant effects of 3-n -butylphthalide (BuPh) and its possible mechanisms of action were investigated in spontaneously hypertensive rats (SHR) for the first time. A 13-day intraperitoneal infusion of BuPh at doses of 2.0 and 4.0 mg/day produced a transient hypotensive effect while a dose of 0.5 mg/day showed a significant hypotensive effect only on day 12. BuPh at 0.5 mg/day had no effect on the plasma and tissue angiotensin converting enzyme (ACE) activities, or on the tissue lipid peroxidation index. BuPh relaxed endothelium-intact and denuded aortic rings precontracted with phenylephrine and KCl. NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, did not attenuate the vasorelaxant activity of BuPh. The cumulative concentration response curves of phenylephrine and Ca2+ (in CaCl2-free, high KCl medium) were non-competitively inhibited by BuPh. However, BuPh did not interfere with the caffeine-induced release of intracellular Ca2+. It appears that the vasorelaxant effect of BuPh could be attributed to the blockade of Ca2+ entry, possibly through voltage- and receptor-operated Ca2+ channels, thereby lowering the systolic blood pressure of SHR.