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Frequently Asked Questions


1.) Can I use AndroGenerator INSTEAD of Anabolic steroids?

Answer: YES! AndroGenerator is designed to maximally increase total and FREE testosterone levels, decrease cortisol, estrogen, and prolactin, and increase HGH and IGF-1 levels, while simultaneously saturating the muscle cells with a matrix of highly anabolic ingredients. AndroGenerator will ENHANCE HPTA FUNCTION, as opposed to steroids which INHIBIT HPTA FUNCTION. Although certain anabolic steroids are far more potent than AndroGenerator, the natural bodybuilder will definitely appreciate the increase in strength and muscle mass that AndroGenerator will produce. Even steroid users will appreciate the pro-androgenic, muscle building effects of AndroGenerator. There is no other natural product that is capable of what AndroGenerator can do. There is nothing as POWERUL as AndroGenerator for producing lean muscle mass, raw strength, sustained endurance, freaky vascularity, and incredible muscle hardness and definition. The AndroGenerator creates the most ANABOLIC environment possible, by using multiple mechanisms of action and multiple pathways to trigger the greatest gains in lean muscle-mass and strength that can be achieved. There is truly NOTHING on the market that can compare to AndroGenerator's incredible MASS-BUILDING, STRENGTH INDUCING effect. Users can easily expect to put on 5-10 pounds within 4 weeks, and continued gains thereafter. The gains experienced on AndroGenerator are dry and hard, as the user will not experience any water-retention at all. The user can expect a general feeling of well-being, a huge increase in libido, and a healthy increase in aggression.

2.) Can AndroGenerator be used instead of Nolvadex and Clomid?

Answer: AndroGenerator will restore HPTA function quickly, safely, and effectively. AndroGenerator stimulates the HPTA from every angle possible. Not only does AndroGenerator drastically increase TOTAL AND FREE TESTOSTERONE, it also decreases CORTISOL, ESTROGEN. and PROLACTIN, the three primary enemies of HPTA recovery in a post-cycle environment! It is imperative to increase testosterone levels, decrease estrogen, prolactin, and cortisol, and to restore your hormonal balance as swiftly and effectively as possible. AndroGenerator features a unique combination of highly anabolic, pro-androgenic agents that drastically increase endogenous ANDROGEN concentrations while simultaneously reducing prolactin and balancing progesterone and Estrogen. You will NEVER use Clomid or Nolvadex again! Nothing else can do this. To FURTHER support an enhanced anabolic state, AndroGenerator supports strength and muscle mass by increasing HGH and IGF-1 levels, while simultaneously saturating the muscle cells with a matrix of highly anabolic ingredients. Clomid and Nolvadex can be used in conjunction with AndroGenerator, and of course, an Aromatase Inhibitor.

3.) Can AndroGenerator prevent HPTA SHUTDOWN & INCREASE GAINS ON CYCLE?

Answer: YES, AndroGenerator will minimize HPTA inhibition and increase your gains on cycle. AndroGenerator will MINIMIZE HPTA INHIBITION, through several different mechanisms. During a steroid cycle, the testicles SHRINK. This is known as testicular atrophy. The testicles shrink as a result of being "SHUTDOWN". They are not functioning to produce testosterone, because the body has ceased all endogenous androgen production as a result of detecting exogenous hormones. AndroGenerator is so powerful and effective, it will actually PREVENT HPTA SHUTDOWN from ocurring while ON CYCLE! While on cycle, the body's natural production of testosterone(and LH) becomes suppressed. Just like HCG, AndroGenerator signals the Pituitary to secrete LH, which subsequently causes the testicles to produce more testosterone. This increase in LH and subsequently testosterone, maintains testicular mass and function while on anabolic steroids. AndroGenerator also decreases PROLACTIN, which is the primary sex hormone responsible for "HPTA sensitivity". Prolactin is a nasty hormone that will cause the HPTA to SHUTDOWN almost immediately, which is why steroids such as Deca and Tren are so suppressive to HPTA function. By decreasing prolactin, we can decrease HPTA sensitivity and further minimize total HPTA inhibition experienced while on cycle. Running AndroGenerator with a mild steroid such as Anavar, Dianabol, or Epistane, will result in virtually no HPTA inhibition at all. Including Androgenerator in your full cycle will result in much less HPTA inhibition and of course, much GREATER GAINS while on cycle, due to the pro-androgenic, muscle-building effect of AndroGenerator.

4.) Does AndroGenerator increase penis size?

Answer: Well, this is a dificult question to answer. Although permanent penile increases have never been substantiated in a clinical setting, many users have reported substantial increases is penile length and girth, as well as a large increase in libido, erection strength, ejaculatory volume, and genital sensitivity, from the main ingredients in AndroGenerator, "LJ100" and "Protodioscin". Many of these aphrodisiac effects have been documented with the active ingredients in Androgenerator and over a dozen clinical trials in Malaysia have demonstrated the pro-androgenic, pro-sexual effect of LJ100. AndroGenerator contains the ONLY natural ingredients shown to increase PENIS SIZE! LJ100 and Protodiocin function mutually to increase blood flow and oxygen to the penis, while simultaneously increasing Testosterone(the male hormone) production at the testicular level. As the male hormone, it is directly responsible for a myriad of cognitive, physical, and psycholgical characteristics that we as males possess. Testosterone increases sexual appetite, vigor, stamina, potency, and fertility. Testosterone increases muscle mass and strength, and restores youthfulness and well-being. Increased testosterone levels translates into an increase in "masculine" characterstics and behavior. AndroGenerator contains the potent ingredients LJ100 and Protodiocin, which not only increase total testosterone production, total free testosterone, and enhance the testosterone to estrogen ratio, but they also directly stimulate the testicles, increase oxygen and bloodflow to the penis, and strengthen the penile muscles responsible for ejaculation and genital control. Sustained penis size increases have been reported, and have been confirmed anecdotally by thousands. AndroGenerator will definitely give you the EDGE in the bedroom that you are looking for.





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References, please.

THE ANABOLIC EFFECTS OF LJ100™
For a printable copy of this study, please click here: http://www.source-1-global.com/pdfs/LJ100-...cal-Studies.pdf


Sareena Hanim Hamzah & Ashril Yusof
Department of Exercise Physiology, Sports Centre, University of Malaya, Kuala Lumpur

Introduction
Eurycoma longifolia (LJ100™) is a tall shrub tree of a Simaroubaceace family and is commonly found along the hilly jungle slopes of Malaysia. It has been used for years as a traditional medicine to treat fever, ulcer, malarial, swelling, reduce high blood pressure and fatigue. However, LJ100 is better known for its aphrodisiac properties. In a clinical study by Ismail (2002), he demonstrated that this herb enhanced sexual activities and increased free testosterone levels in men. Increases in testosterone levels is associated with an improvement in fat free mass, muscle size and muscle strength in men (Brodsky, 1996; Bhasin, 1997), which could be further amplified by strength training (Bhasin, 1996). In this study, the effect of LJ100 water-soluble extract on body composition and muscle size in men will be measured.

Methods
Fourteen healthy adult males (age 25.64 ? 3.73 years) received either 100 mg/day LJ100 water-soluble extract (n = 7) or placebo (n = 7) for 8 weeks. Simultaneously, both groups performed an intensive strength-training program with initial load of 60% repetition maximum (RM), which was carried out on alternate days. A total of 10 exercises, which make up the circuit, were catered towards providing a total lower body and upper body workout. Each workout was done in two sets of 10 repetitions with 1-minute rest in between. The loads were gradually increased 10% per week. Body composition measurement using skin fold test was taken at two sites as recommended by McArdle (1993). A standard strength test that comprised of 1 RM test was administered on the subject to determine their strength. The upper limb strength was measured by determining their ability to resist maximum load using the shoulder press machine (Nautilus, USA) following the American College of Sports Medicine (ACSM, 2001) standard measurement procedure. The arm circumference measurement was taken using a measuring tape at proximal 1/3rd of the arm. Electromyography reading of the isometric contraction of bicep muscle was taken using the surface electrodes. Subjects were instructed to perform an isokinetic flexion of the elbow using free barbells with load of 10 kg for the durations of 5 seconds. The mean amplitude was analyzed using the MyoResearch Software (Noraxon, USA).
All the measurements were taken 1 day prior to supplementation (LJ100 and placebo) and training period, and 1 day after the completion of 8 weeks experiment. All data were analyzed using the Statistical Package for Social Science (SPSS) computer software version 10.0 (2000) for t-test, means and standard deviation. Statistical significance was established at p<0.05.

Results
The results for fat free mass, fat mass, 1 RM, arm circumference, and sEMG of both groups are shown in Table 1.

Table 1. Average fat free mass, fat mass, 1 RM test, arm circumference and sEMG of the group consuming LJ100 water soluble extract and placebo before and after the period of supplementation and training program


* Results of mean ± SD for pre and post experiment showed significant difference (p<0.05)

The fat free mass of the group supplemented with LJ100 water-soluble extract showed a significant increment of approximately 2.1 kg. There were no significant changes in fat free mass in placebo. Body fat percentages were significantly decreased in treatment and placebo. However, a greater decrement was shown in treatment compared to placebo i.e. 9.14% and 6.57%, respectively. The 1 RM test muscle strength test showed an increase in gross muscle power in both groups. The treatment group showed a greater increment in strength compared to placebo i.e. 6.78% and 2.77%, respectively. The mean arm circumference in treatment group increased significantly by 1.8 cm following the supplementation while no significant changes observed in placebo group. The mean sEMG reading of the treatment and placebo showed a significant decrement in values after going through the exercise program. However, the treatment group showed 2.92% higher reduction in electrical activity of the muscle measured at the end of the experiment period compared to placebo (25.70% and 22.78%, respectively). During and after the administration of LJ100, no adverse effects were noted within the treatment group.

Discussion/ Conclusion
In this study, although the testosterone level was not measured during the test period, an increased in fat free mass in treatment group may be linked to the rise in steroidal hormones in the body. The percentage of body fat appeared to decrease in both groups, this finding is in agreement with a study by Brodsky (1996). However, the further decrease in fat mass by the treatment group could be explained by the higher metabolic rate after consuming LJ100. The increment in muscle strength with strength training in both the treatment and placebo groups were consistent with the finding by Kraemer (1993), he suggested that the improvement in strength was caused by the increase in testosterone levels. Jones and Round (1996) proposed that increases in strength are greater than increases in muscle size during the first 6-8 weeks of strength training. Thus, an increase in arm circumference observed in treatment group could be explained by the testosterone enhancing effect of the extract. In conclusion, results obtained from this pilot study suggest that the administration of LJ100 improved fat free mass, reduce fat mass, increase muscle strength and size suggesting LJ100 might be used as an ergogenic aid. Further studies will be carried out to determine the mechanism of action at hormonal and molecular level.

Water-soluble extract of LJ100™ as a potential
natural energizer for healthy aging in men.
M.I.M.TAMBI1, S. OTHMAN2and J.M SAAD2

1Specialist Reproductive Research Center, National Population & Family Development Board, Ministry of Women & Family Development, Malaysia.
2Department of Biochemistry, Faculty of Medicine, University of Malaya, Malaysia.

Introduction
Malaysia has a rich source of rainforests that contain thousands of plants with potential medicinal values. One such plant is the tall shrub tree from the Simaroubaceace family, Eurycoma Longifolia (LJ100™ Tongkat Ali) which is commonly found along the hilly jungle slopes of Malaysia (Burkill and Hanif, 1930). The local name of the shrub is 'Tongkat Ali' or Ali's Walking Stick' which is rather suggestive of its traditional function of sexual support for aging males. Similar trees are also found in other Asian Rainforests; however, it is traditionally known that only two species of the shrub namely E.Longifolia and E.apiculata have medicinal properties (Burkill and Hanif, 1930). The medicinal elements are only found within the roots. The root of Eurycoma Longifolia was used as a decoction by the natives of old Malaya, especially the elderly for strength and energy (Burkill and Hanif,1930), this practice remains to this day.
Early experimental studies on animals were mainly focused on the aphrodisiac properties of LJ100. Mice treated LJ100 demonstrated higher frequency of mounting compared to the control group (Ali and Saad, 1993). Additionally, the serum testosterone of the dissected mice showed an increase of 480% compared to the placebo-controlled group (Ali and Saad, 1993). Further studies provided evidence that LJ100 produced a dose-dependent increase in mounting frequency in male rats, hence, acting as a potent stimulator of sexual arousal in the absence of feedback from genital sensation (Ang and Sim,1997). It was also shown that LJ100enhanced and maintained a high level of crossovers, mountings, intromissions, and ejaculations.

Other studies showed that when the extract of LJ100 was injected into male mice, they showed intense physical activities and copulatory behavior (Ang and Sim, 1998). Even frail mice were observed to be active and alert. In another study, LJ100 was exposed to penile muscular tissue of male mice; results demonstrated that the muscular tissue was found to relax. Analysis on the mitochondria homogenates of the liver and penile muscle of the mice showed that the extract could enhance the respiration of mitochondria, leading to 60% increase in ATP production through oxidative phosphorylation (Khamis and Saad, 1993).

Early clinical trials studied the effect of LJ100 on testicular tissues. The samples were incubated along with human testicular tissues taken from men who were orchidectomised as part of treatment of prostate cancer (Aminuddin et al, 1995). There was significant increase in the concentration of testosterone and its precursors. The results suggest that the LJ100 has the ability to increase the biosynthesis of androgens (Aminuddin et al, 1995).


Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates. This includes the activity of the accessory male sex organs and development of male secondary sex characteristics. The primary, and most well known, androgen is testosterone.

In this study, we intend to investigate the effect of the LJ100 water-soluble extract on testosterone, dehydroepiandrosterone (DHEA) and sex hormone binding globulin (SHBG) levels in human subjects. Dehydroepiandrosterone (DHEA) is a natural steroid hormone produced from cholesterol by the adrenal glands. Dehydroepiandrosterone is structurally similar to testosterone and estrone and can be easily converted into those hormones (DHEA is a precursor for testosterone). Sex hormone binding globulins are carrier proteins that regulate the amount of unbound steroid in the blood. A decrease in SHBG is associated with an improvement in free testosterone index. Additional parameters that will be measured include Quality Of Life (QOL) via the PADAM score and Sexual Health Inventory Questionnaires (SHI-Q).

Methodology
In a Reproductive Research Center in Kuala Lumpur, Malaysia, 30 human volunteers were recruited in a randomized open trial. The volunteers were selected among married men whose age ranges between 31-52 years. There were no other specific criteria for the selection of volunteers. Dr. Johari M. Saad and co-workers from the Department of Biochemistry, University Malaya, Malaysia, produced LJ100 water-soluble extract of E.Longifolia root.
Upon registration, the volunteers were asked to fill out two questionnaires: (i) a validated Sexual Health Inventory Questionnaires (SHI-Q) and (ii) the PADAM Score Questionnaires. Peripheral venous blood sample was collected from each individual to evaluate his total testosterone hormone, dehydroepiandrosterone sulphate (DHEA) and sex hormone binding globulin (SHBG) levels. Following this, each volunteer was given a supply of the encapsulated LJ100. These were to be consumed regularly for three consecutive weeks, twice daily, and two capsules per day (100 mg/day). The volunteers were requested to come back for a follow-up after week one and week three. During the follow-up sessions, they were asked to again fill out two sets of questionnaires and provide blood samples for analysis of serum testosterone, SHBG and DHEA.

Results
Questionnaires Analysis
Analysis of the SHI-Questionnaire results have shown that 62% of the cases had either increased or a maximum score after consuming LJ100. Another 24% showed reduction while 14% of the cases showed no change in the score (Figure 1). This indicates that the majority of the volunteers demonstrated an increase in their sexual health satisfaction and performance. Breakdown of the SHI-Questionnaire showed subjects has an increase in sexual desire and the success at the attempts at sexual intercourse.


Figure 1: Effect of LJ100™ consumption on SHI-Q Score


PADAM Analysis
Analysis of the PADAM Score demonstrated that 82% of the cases showed a decrease in total score (decrease is positive effect). There is 91% improvement in the sexual PADAM score component, a 73% improvement in the physical component, and an 82% improvement of psychological component. The vasomotor score showed improvement in 50% of the subjects (Figure 2). The improvements in the first three components of the PADAM score reflects that consumption of LJ100 had resulted in an improvement of their quality of life with regards to their physical, sexual and psychological well being.

Figure 2: Percentage of Improvement or Reduction for Various Components of the PADAM Score




Serum Hormones analysis
Testosterone
Total testosterone levels were not significantly different between those raised (43%) and those declined (39%) in this study (Table 1). This gives an initial impression that LJ100 does not have any effect on steroidogenesis. Considering that almost all the volunteers have normal levels of total testosterone, the feedback system is activated to ensure the testosterone levels are within the individual needs range. In 6 volunteers whose serum total testosterone is low, there is an increase in total testosterone on first and third week as well as improvement in the Quality of Life Scores (SHI-Q and PADAM Score).



DHEA
Analysis of the DHEA showed gradual increase from 26% after 1 week to 47% after 3 weeks. This suggests that LJ100may influence the DHEA production, which subsequently would be aromatized to testosterone (Figure 3).

Figure 3: Percentage of Increment in DHEA level



SHBG Analysis
The results showed that SHBG levels were reduced in 36% of the cases after one week and improved to 66% after 3 weeks. This suggests that LJ100 could have an effect on the production of SHBG (Table 2).



Free Testosterone Index Analysis (FTI)
When the SHBG level declines, the Free Testosterone Index (FTI is calculated as a percentage of the total testosterone against SHBG) goes up. Results demonstrated that the FTI increased in 39% of the subjects after 1 week to 73% after 3 weeks (Table 3)



Conclusion
Increasing testosterone is the key factor in increasing sex drive. Testosterone is the most important of the male sex hormones, known as androgens, produced in the gonads. Testosterone plays a key role in the development and maturity of male sex organs. The hormone promotes secondary sex characteristics, including the appearance of facial hair, sexual desire, and sexual behavior. However, testosterone is not just a sex booster for men. Women also produce testosterone, about 5 to 10 percent the amount produced in men. In woman, this vital hormone also stimulates sex drive and produces heightened sensitivity of erogenous zones.

In this study, the aqueous LJ100 extract has a strong potential in providing sufficient free testosterone to the body as demonstrated by the increase in the free testosterone index between weeks one and three. The high score in the Physical and Sexual Domain of PADAM and the Desire and Sexual Attempts in the SHI-Q score suggests this extract can delivery sexual health effects for both men and women.

The results demonstrated that the circulating androgen concentration affects SHBG synthesis. The increase in DHEA levels (DHEA is a precursor to testosterone) between week 1 and week 3 resulted in elevated testosterone levels that caused a decrease in SHBG levels. It is important to note the any decrease in SHBG levels has an overall effect to increase free testosterone index as indicated in table 3. The results of this study suggest that LJ100 inhibits SHBG allowing more free testosterone to remain in the blood. This additional testosterone stems the aging process, improves energy and sexual function, and helps reduce body fat and reduces the risk factors associated with heart health.

Since this study is just an exploratory study to look into the marketing potential of LJ100, the volunteers were asked about personal feedbacks with regard to the extract. The following responses were received:
48% felt that they are feeling healthy, not easily tired, feeling active and energized.
40% felt easily aroused, increase sexual desire and maintained an erection longer.
16% felt their joints and backache are feeling better.
24% felt warm and easily sweat (sign of better circulation)
8% experience better sleep.
8% felt an improvement in their memory.
20% felt their appetite has improved and their bowel movements are better than before.

References
1.Burkill, IH and Hanif, M; (1930) Malay Village Medicine, The Garden Bulletin Strait Settlements.
2.Ali, JM and Saad, JM (1993); Biochemical effect of Eurycoma Longifolia Jack on the sexual behavior, fertility, sex hormone and glycolysis. Dissertation Paper for Bachelor of Science, Department of Biochemistry, University of Malaya
3.Ang, HH and Sim,MK (1997); Effect of Eurycoma Longifolia Jack on sexual behavior of male rats. Archives of Pharmacal Research (Seoul),20(5),656-58
4.Ang, HH and Sim,MK (1998)[1]; Eurycoma Longifolia Jack and orientation in sexually experiences male rats. Biol and Pharmaceutical Bulletin 21(2);153-55
5.Ang, HH and Sim,MK (1998)[2]; Eurycoma Longifolia Jack increases sexual motivation in sexually naive male rats. Archives of Pharmacal Research (Seoul),21(6),778-81
6.Khamis, ZM and Saad, JM (1993); Dissertation Paper for Bachelor of Science, Department of Biochemistry, University of Malaya.
7.Aminuddin, N; Saad, JM; Hadi, AH and Abdullah, R (1995); The effect of Eurycoma Longifolia extracts on androgen synthesis.


LJ100™ Saliva Testosterone Test

Saliva Testosterone Test of 9 Individuals 26-52 years of age
Dosage 2x2 (50mg/capsules) morning & evening for 10 days
Normal range for athlete 800 = 150ng/dl of blood


Volunteers 1-5 are athletes - data are an average of 3 different studies at different times
Volunteers 6-9 do not exercise on a regular basis

Conclusion
The results demonstrate that 100 mg per day of LJ100 caused an increase in bioavailability testosterone within 10 days. Furthermore, all subjects (athletes and non-athletes) showed a positive increase in testosterone suggesting that LJ100 causes an increase in the free testosterone index.

Effect of LJ100 Tongkat Ali on Anabolic Balance During Endurance Exercise

Talbott S, Talbott J, Negrete J, Jones M, Nichols M, and Roza J. Effect of Eurycoma longifolia Extract on Anabolic Balance During Endurance Exercise. SupplementWatch, Inc. Draper, UT, 84020 USA and Source One Global Partners, Chicago, IL 60611 USA. smtalbott@supplementwatch.com

Eurycoma longifolia, commonly known as “Tongkat Ali” or “Longjack,” is often touted as a testosterone “booster” and marketed to athletes as a training aid and performance enhancer. Rodent studies have shown oral delivery of Eurycoma extract to improve sexual performance and increase serum testosterone levels. Open-label human trials have suggested that Eurycoma extract may help prevent age-associated androgen deficiency, improve sexual function, and increase psychological parameters such as mood, energy, and sense of well-being. The purpose of this study was to determine the effects of Eurycoma longifolia on testosterone and cortisol levels during intense endurance exercise. We used a water-soluble extract of Eurycoma longifolia (E) standardized to 22% eurypeptides and 40% glycosaponins. Male subjects (N=30) were recruited from a 24-hour mountain biking event and asked to provide a saliva sample before and after each lap for measurement of cortisol and testosterone by enzyme immunoassay (Salimetrics, State College, PA). Subjects completed 4 laps (14.91 miles/lap) and provided 8 saliva samples over a 24h period. Subjects consumed 100mg of E or a look-alike placebo (P) approximately 30 minutes prior to endurance exercise. Cortisol levels were 32.3% lower in E compared to P (0.552+0.665 versus 0.816+0.775 ug/dL, P < 0.05). Testosterone levels were 16.4% higher in E compared to P (86.72+40.90 versus 72.47+33.77 pg/mL, P < 0.05). These results suggest that Eurycoma longifolia extract may help to maintain normal levels of cortisol (low) and testosterone (high) and thus promote an overall “anabolic” hormonal state (versus a “catabolic” state characterized by elevated cortisol and suppressed testosterone) during intense endurance exercise.

TRIBESTAN EFFECT ON THE CONCENTRATION OF SOME HORMONES IN THE SERUM OF HEALTHY SUBJECTS

S. Milanov, A. Maleeva, M. Taskov

RIRR - Radioisotope and Radioimmunological Laboratory, Sofia

Chemical Pharmaceutical Research Institute,
Sofia, Bulgaria

SUMMARY

Tribestan effect has been studied on the serum concentration of hypophyseal hormones, of ACTH, STH, LH, FSH, adrenal hormone aldosterone and cortisol and sex hormones - testosterone and estradiol. The experiments have been carried out on 8 males and 8 females, aged 28 - 45 years of age. The product was perorally administered in a single dose of 250 mg, three times daily for 5 days. Serum samples were withdrawn at 8 a.m. and 12 a.m., prior to and post treatment. The product has been established not to change essentially the concentrations of adrenal hormones and of ACTH. The hypophyseal-gonadal axis however has significantly been affected in the females with predominantly increased concentration of FSH and estradiol and in the males - mainly of LH and the testosterone. The mechanism of that action is presumed to be complicated and realized both by direct effect on gonadal apparatus and by the tropic hormones.
The probable established changes in the concentration of the hormones studied do not get out of the frames of the physiological limits.

The lyophilized extract of Tribulus terrestris, introduced in veterinary practice as TB-68, has pronounced sex-stimulating function. The initial studies of this product showed that it stimulates the spermatogenesis of albino rats (Vankov S., et al., 1973) and enhanced the ovulation of female rats (Vankov S. et al. 1973). Zarkova S. (1976) has also established in rats an increased number of spermatogonia, spermatocytes as well as increase of neutral mucopolysaccharides in seminiferous tubules of the testes. Gendzhev Z. and S. Zarkova, in other experiments (1978) proved the increase of spermatic reserve in the epididymis of rats.

With the view to the need of human medicine of a product stimulating sexual function, Tribestan was formulated on the base of the indicated phytochemical product. It contains saponins of furostanol type (Tomova M. et al., 1978). The first studies of Tribestan confirmed its high sex-stimulating activity in experimental animals (Zarkova S., 1981). Later, the clinical studies established a similar stimulating effect in humans as well (Protich M. at al. 1981). The present study was carried out with a view to throwing light on some aspects of the mechanism of that action of Tribestan, aiming at attaining an effect from the product on the serum concentration of some hypophyseal, sexual and adrenal hormones.

MATERIALS AND METHODS

The experiments were performed on 16 subjects (8 females and 8 males), aged 28-45. All subjects were in good health, without any complaints and good capacity for work. The following schedule was used:
1. The basic levels of hypophysiotropic hormones (ACTH, STH, LH, FSH), of sexual hormones (testosterone and estradiol) and of adrenal hormones (aldosterone and cortisol) were determined. They were determined twice, at 8 a.m. and 12 p.m. - one day prior to Tribestan treatment.
2. The treatment with the product was initiated on the following day, which was periodically administered, 250 mg, three times daily for 5 days.
3. After the termination of Tribestan treatment (day sixth after the initiation of the experiment), blood was again withdrawn (at the same hour - 8:00 a.m. and 12 p.m.) for the determination of the concentration of the indicated hormones.

The work proceeded in the following way: after centrifugation of 6 - 8 ml blood, the serum obtained was frozen at 20°C till the day of the determination of hormonal concentration. The determination was performed by radioimmune tests. LH and FSH were determined by the modified method of Midgley A.R., (1967), making use of some kits of Biodata company, Italy and ACTH and STH - according to the method of Berson S.A. and R. S. Yalow (1963). Testosterone was evaluated by the method of William R. H. (1968), and of estradiol by Orezyk G.P. et al. (1974), making use of kits of Sorin Company, Belgium for both hormones. The adrenal hormones cortisol and aldosterone were also determined by kits of that company, making use of Vescei P. (1974) and of William G and R. Hunderwood (1974).

The obtained results were statistically processed by variation analysis, by Student - t test.

RESULTS AND DISCUSSION

As could be seen from Table 1, LH level in the males was elevated with a high significance after the treatment (p < 0.001). The changes affected both samples to the same rate (at 8 a.m. and 12 p.m.). FSH concentration was not affected under the same conditions. The other two hypophyseal hormones, ACTH and STH were not changed.

An insignificant tendency to elevation was observed in STH level (mean values - 2.9 prior to and 3.2 mg/ml post treatment) in some of the cases. The level of sex hormones was strongly affected. Thus testosterone concentration was three-fold (2) increased and that of estradiol - about 1.5 times (Table 1).

Table 1
Hormone Prior to Tribestan
Post Tribestan

8 a.m.
12 p.m.
8 a.m.
12 p.m.

LH, mIU/ml X 13.0 14.38(1) 37.25 24.75
SX 0.64 0.73 1.01 0.79
Pt 0.001 0.001
FSH, mIU/ml X 13.38 13.50 13.38 11.38
SX 0.35 0.28 0.35 0.36
Pt >0.5 >0.5
Testosterone, ng % X 628 610 882 845
SX 48 46 35 32
Pt <0.001 <0.001
Estradiol pg/ml X 79 76 133 137.5
SX 3.46 2.24 6.72 5.86
Pt <0.001 <0.001

LH concentration was also increased in females under Tribestan effect. What impressed was that the significance was lower than the first sample. The greatest discrepancy, as compared with the results of the males, was the sharp stimulation of FSH. A strong effect was observed there, which could be explained by blood withdrawal during the early phase of the menstrual cycle, the so-called follicular phase. Estradiol was also strongly affected (Pt < 0.001), whereas testosterone in the females during the early hours of the day was less affected (Table 2).

Table 2
Hormone
Prior to Tribestan
Post Tribestan

8 a.m.
12 p.m.
8 a.m.
12 p.m.

LH, mIU/ml X 15.25 13.50 17.13 16.88
SX 0.64 0.87 0.73 0.35
Pt 0.02 0.001
FSH, mIU/ml X 11.00 11.88 17.75 15.25
SX 0.13 0.09 0.71 0.38
Pt 0.001 0.001
Estradiol mIU/ml X 72.13 59.38 77.13 87.50
SX 6.02 5.73 5.47 3.24
Pt 0.5 0.001

The level of adrenal hormone was identically affected both in males and females (Table 3). A significant increase of the concentration was also established though that effect had a relatively low significance (p < 0.05). At the same time, cortisol level was no changed (Table 3).



Table 3
Aldosterone Cortisol
Prior to Post Prior to Post
X 11.59 13.77 8.63 8.63
S 2.52 3.48 2.20 1.92
SX 0.63 0.87 0.55 0.48
Pt 0.05 0.05

The results obtained provided grounds to admit that Tribestan had a pronounced stimulating effect on the secretion of some hormones. The effect on the hormones along the hypophyseal-gonadal axis was particularly well manifested. The effect was manifested both at hypophyseal and gonadal level. Some sexual discrepancies were also established. Thus, FSH was mainly affected in the females. The presence of that hormone is exceptionally important during the follicular phase for the development of the follicle. When its development is stimulated, its secretory ability is also intensified and hence - estradiol level is elevated. Lutenizing hormone is more strongly influenced in the male, which on its part stimulates the secretion of testosterone.

ACTH and cortisol were not changed suggesting that they were not significantly involved in the realization of Tribestan effects. The tendency of stimulation of STH and aldosterone explained the activation of the anabolic processes in the body and general stimulating action of the product. The absence of effect on the level of cortisol showed however that the general tonic action was very strongly manifested.

It should be stressed that the level of the hormones studied did not go out beyond the physiological frames i.e. it did not disturb the physiological mechanisms of hormonal regulation.

References

Vankov S., S. Zarkova, Z. Gendzhev, M. Tomova - Effect of TB-68 on the spermatogenesis in albino rats. Proceeding of the Third National Conference of Pharmacology and Clinics of New Bulgarian Drugs, Sofia, November 14-16, 1973, v.2, 161-163.
Vankov S., S. Zarkova, M. Tomova - TB-68 effect on ovulation of albino rats. Proceedings of Third National Conference of Pharmacology and Clinics of New Bulgarian Drugs, Sofia, November 14-16, 1973, v.2, 165-167.
Gendzhev Z., S. Zarkova - Effect of the phyto-pharmaceutical TB-68 on the number of spermatozoa in epididymis of rat. Med. Archive, 1978, N I, 113-118.
Dimova P., M. Taskov - Comparative enzyme-histological studies of some phyto-products. MBI (at the printer's), 1981.
Zarkova S. - Morphological and histological changes in testes of rat under the effect of TB-68, Med. Archive, 1976, N 4, 49-53.
Protich M., D. Zvetanov, V. Nalbanski, R.Stanislavov, M.Kazarova - Clinical trial of Tribestan on infertile males, MBI (at the printer's).
Tomova M., V. Gyulemetova, S. Zarkova - Author's certificate N 77584 A 61 K 35/1978.
Berson S.A., R. S. Yalow - Immunoassay of protein hormones, The Hormones, Vol. V, Acad. Press., New York, 1963.
Midgley A.R. - Radioimmunoassay for Human, J. Clin. Endocr., 1967, 27, 295.
Orezyk, Gaylo P., Burton v. Caldwell, Harold H. Behrmaan - Methods of Hormone Radioimmunoassay - Ed. B. Jaffe, H. Berhmaan, A6. Press, NJ, London, 1974, 333-343.
Vescei P. - Glicocorticoids: Cortisol Corticosterone - Methods of Hormone Radioimmunoassay; Ed. B. Jaffe and H. Behrmaan, Ac. Press, NJ, London 393-412.
William R.H. - Textbook of Endocrinology 4th Edit. Saunder, Philadelphia, 1968.
Williams Gordon H., Richard H. Hunderwood - Methods of Hormon Radioimmunoassay; Ed. B. Jaffe and H. Behrmaan, Ac. Press, NJ, London, 1974, 371-390.

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http://www.outlawmuscle.com/forum/forumdisplay.php?f=94

SNAP INTO A SLIM JIM!!!

Heh, c'mon, it makes your jimmy thicker?

I can believe the other stuff.

It is possible, many have reported just that. I can confirm that it does increase the quality of erections so significantly that you may experience the largest erections you have ever experienced.

As you will learn, a supplement ONLY works after VC says it does

Lol. And unfortunately he hasn't been around for quite a while. Anyone know where he is?

Last I heard he was in Afghanistan loading poppy extract onto camels to Karachi, where his junk is in the harbor. For like leanness.

androG for life

I know Ross and he is the real deal, AndroGenerator has gotten sick feedback

From what I gather he's been successful with IF to the point of not having interest in dabbling with experiments on supplements for body composition benefit.

I did enjoy reading his postings.

Just to nit-pick [], 'aromatized' is used incorrectly above.

Thanks my friend! For those who wanted to see some LOGS, check out these: http://www.supremesportsfitness.com/viewforum.php?f=21

Giving out 3 bottles!! SPEAK UP NOW!:)

I'd give it a whirl and log it here. I'm cutting, so this might be nice to run. I use nothing but fish oil, bcaas and sesamin currently. I'm a little more interested in omni though to tell you the truth. I've been thinking of adding BA for a while now.

Out of the 2 products this one is more interesting to me.

I think naturally I have benefitted from lowered prolactin via vitex. I note good libido enhancement from my trials with trib in the past. I have heard good reports of Eury from some people I know so I am curious about how I would respond. Combining all 3 might be the ticket to a good natural modulation.

Can you talk about why some manufacturers place both GPA and creatine in the same product?

I would be interested, I think.

Hell, I'd even post a neat feedback log. (Eventually)

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There is an INCREDIBLE synergy between Creatine and GPA, primarily because of the different mechanisms of action. GPA actually increases endogenous creatine, so supplementing with exogenous creatine is more beneificial. It also increases the amount of total creatine a cell can hold.

Guanidinopropionic Acid (N-(aminoiminomethyl)-beta-alanine) is a creatine monohydrate analogue. GPA helps to regulate insulin function and produces remarkable synergy when co-administered with Creatine. Its actions have been compared to those of the drug glucophage. 3-GPA mimics the positive glycemic properties of carbs, which include transporting nutrients, loading muscles with glycogen for fullness and vascularity, supplying readily accessible energy sources for intense training. Guanidinopropionic Acid eliminates the negative effects of carbs, which include storing excess carbohydrate calories as fat and negatively affecting energy levels by causing rapid rises and falls in blood sugar levels.

Great! Send me your shipping addy and username to Ross@SupremeSporrtsFitness.com

ENJOY!

YES! BEST POST 2K8!

SAMPLES SENT!

Please call our customer service at 1800-777-0901 to track your package, 9am-5pm, Mon-Fri

GET READY FOR SOME LOGS!

We should have some great logs here on M&M this week. for now check out http://www.supremesportsfitness.com/index.php

ttt

SSE: Check your thread in your sub-forum for questions on this...and thanks for the FAST shipping!

Fastest shipping ever!

No offense, but I wouldnt support or take a supplement from a company who comes out with a product named "Vicodene" ... "Natural Pain Killer"

Did you READ that we are CHANGING THE NAME? http://www.supremesportsfitness.com/viewforum.php?f=34

Would you take an OTC Anti-E called "Novadex"(Gaspari) instead of "Nolvadex"? Or how about "Tea-3" instead of "T-3"?

Lots of companies create supplements named after existing pharmacetical drugs for marketing purposes. We are simply changing the name, for the reasons cited in the above thread.

Sorry but, naming a supplement after an extremely addictive narcotic, is completely different than naming a supplement after a anti-estrogen, or thyroid medication.

Point being...it was a horrible business choice to do that...like the supplement industry needs anymore unwanted attention...

We agree, wich is why we are changing the name.

ttt

Actually IMO, Gaspari using the name "Novadex" is much much much worse. Why? Because uninformed consumers will assume this is "NOLVADEX" and use it for their pct.

I think you both have valid points..i guess it breaks down to individual consumers....anyways, I think it sounds like great stuff...Id be up for trying some......let me know.

FLMEDIC911

Sure, i'll send you a bottle, EMAIL me your username and shipping addy.

ENJOY!

So where's the rest of the testers? I'm the only one with a log...

Error: on the front it says 150 capsules, while serving size states 5 tablets.

Never received O-bol.

Nice catch.

150 tablets per bottle, 5 tablets per serving.

We already fixed on next label.

It doesn't say 150 tablets on the front of the label, it says 150 capsules

capsules !=tablets.

Re-read my post, I misunderstood you

Gotcha...no worries, just trying to help.

I always appreciate mistakes being pointed out on my labels so I can correct them as well.

call it No-Pain Gain NPG

ttt

lots of logs started!

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I know that its counterintuitive, but I've experienced much better results when taking a GPA containing creatine product rather than one without. Also, while taking phenogen (GPA without creatine) I didn't experience results anywhere near those when combined with creatine.

I think that there's much more to the picture than the anti-creatine properties of GPA. Honestly, I haven't done enough research on this compound and really need to catch up on my reading.

Anyways, this looks to be a product that I'd really like to try. I may have to pick some up in the future.