Dim does not lower E2. it only changes the metabolic pathway from 16 to 2 and can possible increase 4 ohe if they are not washed down stream by proper methylations. On 50 mgs iodoral, 300 DIM (patent one), 1000 mgs TMG for 8 months has done shit for me in reducing my 16/2. I have been on 2 different kinds and has not budget them one bit. I know the 4 and 16 are my problems but for life of me can not drop them. My problem is methylation is under active. TMG, SAm-e has not helped. I just got a script for methy b-12 shots hopefully that will open up the metabolic block. I know that the 4 ohe can act as a bottle neck shutting down the COMT enyzmatic pathway as well. Jansz and I have the same issue, but I will solve this riddle. One possibility is that progesterone defieincy resulting in improper magneisum uptake as indicated on my urine test showed up low pregnanetriol which is a by product of 17 hyrdoxprogesterone. I know magnesium is needed for COMT and for some reason on my last spectra cell test my magnesium levels where dropping.
This leave me 4 possblites
1. Pregneolone creame will increase conversion to progesterone to offset nasty effects of estrogens at the cells receptors. By increasing progesterone with preg TD this may increase magnesium absorption since progesterone is needed for this to occur. Before when I was on preg cream my e2 was right in check at 22 with TT of 900 no armidex.
2. Oral methy b-12 have done crap and by swithcing to the injections this should remove the metabolic block and get methylation moving in the right directions.
3. As last resort genovations SNP testing to test to see if there are genetic intervation that may be at the route cause of the issue.
4 iincrease the DIM to 450 mgs a day, but this could make matters worse since it could raise the bad estrogen mainly 4 ohe even higher.
Most logical choice is to open up the methylation block, but unsure of how