QUOTE(Primordial Performance @ Feb 29 2008, 01:01 PM) [snapback]462377[/snapback]
The bodybuilding related benefits have to do with Toco-8's positive effect at increasing the pituitary concentration of LH/FSH, and increasing the testes sensitivity to these gonadotropins.
-Pp
The three studies referenced (9-11) on the Primordial Performance Toco-8 webpage refer to vitamin E deficiency (actually no mention of tocotrienols). Don't get me wrong I like tocotrienols for the myriad of health benefits. It also looks like a grade A hair regrowth product (that is actually good for you). Here are the abstracts of the referenced studies:
AKAZAWA, N., MIKAMI, S. and KIMURA, S. Effects of Vitamin E Deficiency on the Hormone Secretion of the Pituitary-Gonadal Axis of the Rat. Tohoku J. exp. Med., 1987, 152 (3), 221-229 Chronological changes of gonadotropin (FSH and LH) and testosterone concentrations in the serum were measured in vitamin E deficient rats to investigate the effects of vitamin E deficiency on the pituitary-gonadal function in rats. The receptor sites and association constant (Ka) for LH and the formation of cyclic AMP in the Leydig cells were also investigated. The results obtained in the present study are as follows: 1) The vitamin E deficient rats showed almost complete hemolysis and extremely increased TBA reacting substances (TBARS) in the serum and liver. 2) The serum LH concentration in the vitamin E deficient group was slightly higher than in the vitamin E supplemented group during the later periods of experiment. 3) The serum FSH concentration in the vitamin E deficient group did not differ significantly from that in vitamin E supplemented group, but became significantly higher than that in the latter at 186 days of experiment. 4) The serum testosterone concentration was always lower in the vitamin E deficient group than in the control. 5) The vitamin E deficient group showed slightly large number of LH/hCG receptor and significantly small Ka (low affinity), as compared with vitamin E supplemented group. The formation of cyclic AMP by Leydig cells decreased significantly in vitamin E deficient group. These results suggest that the vitamin E deficiency exerted a suppressive effect directly on the gonadal function to decrease the hormone synthesis in the Leydig cells and caused the increased secretion of pituitary LH owing to the feedback mechanism.
-------------------------------------------------------------------------------------------------------
UMEDA, F., KATO, K., IBAYASHI, H., KOJIMA, M., SHIBATA, Y. and YAMAMOTO, T. Inhibitory Effect of Vitamin E on Lipoperoxide Formation in Rat Adrenal Gland. Tohoku J. exp. Med., 1982, 137 (4), 369-377 - The tissue uptake of vitamin E administered to the rats was strikingly high in the adrenal glands, and microradioautographic studies showed that the vitamin was localized morphologically in the cells of fascicular and reticular zones of the adrenal cortex, where lipofuscin pigment appears with aging. On the other hand, it was confirmed that the TBA content in rat plasma and adrenal gland was elevated following whole-body 60Co irradiation as an aging model. It was also demonstrated that the TBA content in rat adrenal markedly increased in conditions of vitamin E deficiency with and without irradiation. - vitamin E; lipoperoxide formation; rat adrenal gland
--------------------------------------------------------------------------------------------------------
The effects of vitamin E deficiency on some enzymes of steroid hormone biosynthesis.
The effect of vitamin E deficiency on three enzyme systems involved in steroidogenesis was investigated. No change was found in vitro activity of cholesterol side-chain cleavage enzyme in adrenal or testicular tissue, or of 11-beta-hydroxylase activity in adrenal tissue. Significantly less 3-beta-hydroxysteroid dehydrogenase activity was found in ovarian tissue from female rats given a diet deficient in vitamin E for 141 days, and in testicular tissue and adrenal glands from male rats given the deficient diet for 280 days. Testicular tissue from male rats given the deficient diet for 91 days showed considerably less 3-beta-hydroxysteroid dehydrogenase activity than did tissue from control rats, but the difference was not statistically significant.