If one is ingesting little to no fat, and one uses DCP, will the salvia in DCP still be effective? My thinking is that it should stop the FFA's floating around in your bloodstream from being taken back up again. Just trying to figure out if this stuff is more useful for those who are ingesting fat, or if it's effective either way.

You're obviously incredibly capable of putting your own diet together and I'm not going to critisize it. Just wanted to know your reasoning behind leaving fat completely out of it...

I'm doing an IF, so during the day I'm eating as little fat and carbs as possible (just protein shakes really). Refeed is after workouts, which is every other day.

Hypocaloric?

I could see this being an issue in a PSMF.

Blocking DGAT post workout probably not a good idea (if you were considering using DCP with your PWO meal)


Enzymes And Exercise Curb Muscle Insulin Resistance
Main Category: Diabetes
Also Included In: Obesity / Weight Loss / Fitness; Biology / Biochemistry
Article Date: 21 May 2007 - 7:00 PST

An oversupply of fatty acids plays a key role in the development of insulin resistance in the skeletal muscle of obese individuals. Two related studies appearing online in advance of publication in the June print issue of the Journal of Clinical Investigation show that exercise and expression of the enzyme diacylglycerol acyltransferase 1 (DGAT1) have important effects on the development of insulin resistance.

In the first of these two studies, Simon Schenk and Jeffrey Horowitz from the University of Michigan have shown that a single session of endurance exercise on a treadmill was sufficient to prevent insulin resistance in healthy, non-obese women. The authors showed that exercise triggered a corresponding increase in triglyceride synthesis within skeletal muscle as well as a parallel increase in the expression of the enzymes DGAT1 and mitochondrial glycerol-3-phosphate acyltransferase (mGPAT). By directing more fatty acids towards triglyceride synthesis within muscle, toxic fatty acid metabolite accumulation was reduced, which protected against fatty acid-induced insulin resistance. The study suggests that regularly performed endurance exercise may help improve insulin resistance in people with excess levels of available fatty acid, such as those with obesity.

In a related study, Yi-Hao Yu and colleagues from Columbia University also observed an increase in DGAT1 activity in skeletal muscle and that fatty acids were channeled into triglycerides following exercise. In addition, the author studied mice that overexpressed DGAT1 in skeletal muscle and found that they were protected against high-fat diet-induced insulin resistance. The data illustrate how exercise can enhance muscle insulin sensitivity and the authors suggest that increasing muscle DGAT activity may offer a potential new approach to prevent and treat insulin resistance in type 2 diabetes.

TITLE: Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance

AUTHOR CONTACT:
Jeffrey F. Horowitz
University of Michigan, Ann Arbor, Michigan, USA

RELATED ARTICLE:

TITLE: Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance

AUTHOR CONTACT:
Yi-Hao Yu
Columbia University, New York, New York, USA

Hypocaloric, yes. I'm mostly concerned about using DCP while PSMF'ing - is inhibiting DGAT going to buy me much if I'm not ingesting dietary fat?

Thanks for the study. It makes sense, as inhibiting DGAT would increase blood FFA's which would in turn decrease insulin sensitivity to carbs. Post workout meal is usually a shitload (e.g. whatever I want as long as there's enough protein).

Blocking DGAT is not simply to prevent dietary fats from being incorporated into adipocytes, but also the FFA that is freed up by the activation of PPAR by TTA.

Cool, this is what I was thinking, I just wanted some confirmation. Thanks.

So with regard to the study Fitnecise posted, the TTA in DCP should help clear the FFA's that would otherwise cause insulin insensitivity, correct? I've seen studies that show improved insulin sensitivity with TTA use.

I'm still a little concerned about TTA + very low calories, but I guess I can ease into it and see how I feel. Have to wait til my Fogo trial is over anyway.

I haven't seen any feedback on DCP usage with significant calorie restriction...can you keep a log?

As far as DCP PWO, I am with Colby on this one...it is much better used preworkout.

Sure thing.

K, thanks for the feedback. I'll stick with Anabolic Pump post-workout and try to keep the fat intake down somewhat.

You'll have a log, as I'll be Velocity Dieting next month for at least 3 weeks.