QUOTE (Benson @ Mar 28 2008, 08:24 PM)

PMID: 10515764, PMID: 12373628 , PMID: 14520600, PMID: 15579328, PMID: 16513152
These all looked at the effect of licorice, not isolated GA, but the hormonal effects appear to be mainly the result of actions by GA on beta-hydroxysteroid dehydrogenase and its kin...
Ah, yeah, I've seen these before. A few notes-
-Whether or not a reduction in testosterone in men is caused by GA is controversial. Some studies have found that licorice reduced testosterone, others have not. In fact, 14520600, which you posted above, even makes note of this. And since licorice contains estrogen-like compounds, as well as glycyrrhizic acid (the other major constituent of licorice that has evidence linking it to reductions in testosterone), the issue becomes even less clear-cut. It could very well be one or more of the other constituents causing the reductions in testosterone that some studies show.
-In the studies where licorice did reduce testosterone (again, licorice as a whole, not isolated GA), most or all appear to measure total testosterone, not free testosterone. In the instances where free testosterone was measured, such as in 14520600, only a slight and statistically insignificant reduction was found.
-Napalm's carrier ensures that the vast majority of ingredients stay localized.
-Pre-treatment hormone levels return to bassline after treatment with licorice stops.
So what we have here are some studies that may or may not be applicable to Napalm (probably not, IMO), since the studies use licorice which is fairly heavy in estrogen-like compounds AND Napalm's carrier is localized. But even if we ignore all of this, we can be pretty certain that
if the GA did decrease testosterone levels, they would return to normal after ceasing Napalm.