Who has used both? How do they compare?

deprenyl. hands down.

Have only used Wellbutrin. It's godsend. I have no reason to try deprenyl. The bupropion covers all bases. Not a very helpful review, but the best would be to try one and if it doesn't leave you satisfied, try the other, and go from there.

I don't like deprenyl very much, it seems to promote everything bad about excess dopamine (anger / irritability, OCD, etc) with only modest, disproportionately small benefits. Bupropion was great stuff initially and propelled me through the most productive period of life I have experienced, but unfortunately it "pooped out" and I was back at my motivational (or lack thereof) baseline.

I'm done beating around the bush with all of these barely effective half-measures. I'm getting some Amineptine.

How funny; my cousin gave me about 5 bottles of Wellbutrin about 2 years ago. I threw them out because I thought I had no need for them, and didn't even bother to look them up. I wish I would have kept them!

I'm on my first week of deprenyl, and so far, so good.

-Angel

Deprenyl and Piracetam is bomb diggity. Inventiveness, fluidity of thought and speech, turned smoking weed back into a nice activity full of clear cognition and creative thinking. I like the increase in OCD like activities, it keeps my place clean as hell. Subl is best, I can now mix it with caffeine or nicotine with no issues. Clean and clear energy all day. Wellbutrin interests me as well, Ill prob mix the two in the future.

I didnt notice anything from deprenyl really until i went past 5mg daily......and the effects werent very good for me but i already have OCD. made me anxious and crabby and obsessive but did have a boost in energy and was waking up earlier in the morning


im on WB xl 150mg rite now.......decent boost in mood, i seem to be a little paraniod and irratable but not to bad

Caffiene I personally have better luck with that either....

It's not really superpowerful. I took 150mg/daily for a couple months. Good mild antidepressant, though I noticed no motivating or focusing effects. I would probably keep some around if it wasn't so expensive.

I think tianeptine is probably better.

The aspect of amineptine's affect that led to the potential for abuse was probably its effects on oxytocin transmission, not its supposed stimulant-like effect. In regards to the latter, amineptine is somewhat similar to bupropion; both inhibit the reuptake of norepinepherine and dopamine. What amineptine could potentially help with is feelings of connectedness to others, trustiness, and things in that department. Extended social isolation can lead to depression, so it isn't surprising that amineptine could be uncharacteristically effective in certain sub-populations of depressives. If that isn't you, however, it isn't likely to help you any more than bupropion would. As an aside, sometimes people feel social disconnect for a reason; it's your brain's way of telling you that you need to find new people.

Have yet to try bupropion. Deprenyl used properly (cycled or taken as needed) works very well.

Depends on what you're looking for...

If you are an anxious person... bupropion will more than likely spike your anxiety even more.

It will also zap your appetite for a little while.

I've been using 150 mg in the morning, and I really like it.

Going to be doing 100 in the morning, and 100 7-8 hrs later starting next week.

Not necessarily true. Bupropion is prescribed for social phobia. I took it for mood and it helped me out a bunch with my social phobia.

really? it seemed to only make my anxiety worse... and I am pretty sure I've read that in many cases.

but wow, if it works for you awesome.

wish it had that effect for me! heh

Were you on an SSRI or anything else? or just bupropion?

Just Wellbutrin XL 150mg for a few months. Still taking the XL, but with Dexedrine spansules now. Good stuff.

You see the same thing with anything that is active on NE/DA- amphetamines kill some folk's social anxiety and mkes them feel confidend, and and others it just makes them anxious, moody, angry and/or OCDey. *shrug*

Bupropion had equal anxiolytic effect as an ssri.

Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of anxiety symptoms in major depressive disorder: a meta-analysis of individual patient data from 10 double-blind, randomized clinical trials.
Papakostas GI, Trivedi MH, Alpert JE, Seifert CA, Krishen A, Goodale EP, Tucker VL.

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. gpapakostas@partners.org

The goal of this work was to compare the efficacy of the norepinephrine-dopamine reuptake inhibitor bupropion with the selective serotonin reuptake inhibitors (SSRIs) in the treatment of anxiety symptoms in major depressive disorder (MDD). Ten double-blind, randomized studies, involving a total of 2890 bupropion-, SSRI- or placebo- treated patients were pooled. Anxiety symptoms of depression were defined using the Hamilton depression rating scale (HDRS) Anxiety-Somatization factor (HDRS-AS) score, as well as the Hamilton anxiety scale (HAM-A) score. Both bupropion and the SSRIs led to a comparable degree of improvement in anxiety symptoms, defined using the HDRS-AS score (-3.8+/-2.8 vs. -3.9+/-2.8, p=0.130) or HAM-A score (-8.8+/-7.2 vs. -9.1+/-7.0, p=0.177). There was no consistent difference in the time to anxiolysis between the two treatment groups. In addition, there was no difference in the proportion of bupropion- and SSRI- remitters who continued to experience residual anxiety, defined as a HDRS-AS score >0 at endpoint (69.2% vs. 74.7%, p=0.081) or a HAM-A score >7 at endpoint (9.5% vs. 8.4%, p=0.284). Finally, there was no statistically significant difference in the severity of residual anxiety symptoms between bupropion- or SSRI- treated patients with remitted depression, defined using the HDRS-AS (1.15+/-1.14 vs. 1.25+/-1.09, p=0.569), or HAM-A scores at endpoint (3.30+/-2.89 vs. 3.31+/-2.89, p=0.552). Contrary to clinician impression, there does not appear to be any difference in the anxiolytic efficacy of bupropion and the SSRIs when used to treat MDD.

I'd say Extended Release Bupropion.

I've had extensive experience with them both.
Deprenyl is ok in low doses for neuroprotection but for the same symptoms you'd take bupropion for.

bupropion is far superior for ADD, Doing stuff, Being social.
also won't make you test positive for amphetamines. (Deprenyl converts partially to L-Amphetamine(the annoying isomer that just creates annoying physical effects) which may explain anxiety issues from people who take deprenyl on a daily basis.)

as for depression.. i'd say MAO-I's > SSRI's

I recently started taking selegiline after reading about all of its positive attributes. However, I was extremely concerned about the potential of it increasing anxiety. I'd assumed that it was somewhat similar to Wellbutrin... and that drug made me a nervous wreck. Dopamine overflow, I suppose.

To my relief, selegiline seems to have anxiolytic effect on me. It's as if it has helped to slow down the racing thoughts, and I'm experiencing the ability to just "pause and reflect" on situations before getting all worked up over every little thing. Those around me have definitely noticed the change. I take 5mg every other day. Daily use made my head feel, well... kinda funny. The sharp concentration I'm experiencing on EOD dosing was decreased significantly on daily dosing. Things got "hazy".

You need to read up more on bupropion which can also cause false-positive urine amphetamine tests. Also the amount of deprenyl's L-methamphetamine/ L-amphetamine metabolite is only in trace amounts hardly enough to cause "annoying physical effects".

The 2007 guideline on the ADHD treatment from American Academy of Child and Adolescent Psychiatry notes that the evidence for bupropion is "far weaker" than for the FDA-approved treatments.

Was not aware about the false positive from buproprion I'll go look into that.

Indeed Wellbutrin is far weaker then FDA approved treatments. The context within that is their first line treatment being Methylphenidate or Amphetamines.
of course wellbutrin isn't going to compete with that.

I was speaking within context of Bupropion vs Deprenyl for Dopaminergic increase.

Clin Chem. 1995 Jun;41(6 Pt 1):955-6.
Bupropion metabolites produce false-positive urine amphetamine results.
Nixon AL, Long WH, Puopolo PR, Flood JG.
PMID: 7768026 [PubMed - indexed for MEDLINE]

Full Article: http://www.clinchem.org/cgi/reprint/41/6/955.pdf

In context of increasing Dopamine Deprenyl would win hands down. A side benefit is increased PEA as well. Not bashing Bupropion as it does has many benefits in it's own right.

Bupropion is much better than Selegiline.

You take Wellbutrin with Dexedrine? How is it? I thought the two together could give seizures or something

Bupropion is a dopamine and norepinephrine reuptake inhibitor, while selegiline inhibits (with relative selectivity) MAO-B, which degrades dopamine and PEA. Both drugs increase dopaminergic transmission, but bupropion does so through the "traditional" pathways of potent dopaminergics like cocaine. MAOIs also tend to interact negatively with other substances/medications, while bupropion is generally safe to combine with other antidepressants (except MAOIs).

Well does Dexedrine lower seizure threshold?

My psychiatrist said bupropion would be fine even though I'm prescribed Adderall 60mg/day.

where do you purchase these things? this is assuming they are legal of course.

Several sources. Only DEA (or few special state laws) controlled ones are illegal.

like online pharmacies?

or your doctor.

Really?! Do you notice a lot of difference than with Adderall alone (when both are taken)? Does it gets you anxious? I wonder if I wouldn't be better taking Wellbutrin rather than Strattera..

How would you subjectively describe Wellbutrin's effects?

That's one hell of a psychiatrist. Needing another stimulant on top of 60mg adderall doesn't sound very good.

Yeah does sound alittle off.

I have used both extensively (deprenyl for maybe 6 months. and wellbutrin for about a month and a half with a SSRI (horrible experience) then tried finishing my dose several months later by itself (no SSRI) and much better results.)
my personal opinion i had better performance day to day with wellbutrin for motivation/focus over deprenyl.

I had more sudden hypertension / sudden shooting jabs of pain in the chest when I took deprenyl.
one of the attacks was enough to bring me to my knees in albertsons for about 5 minutes while I hoped
it would fade away so the concerned people standing around wouldn't call the ambulance.
(yes... doctor the positive l-AMP in my system is from a neurotropic. honest. don't tell my insurance.)

but as steve candidly pointed out. I may have been dosing excessively so my experience is likely an abberation.
I was taking 5mg every other day or sometimes daily
and taking StimX on top of that for studying occasionally.

Wellbutrin is a stimulant? Didn't know that...

I'm not sure if I would call it extensively (I've used deprenyl for well over 10 years) and never had any issues aside from overstimulated.

If you were taking wellbutrin the doctors would have had a positive drug test as well.

is wellbutrin a bad combo with adderal? also what about if i was taking wellbutrin alone but started to get a little anxious, i also have some efexxor that i cold take.

It was in the interest of treating an underlying depression/blank feeling, amirite?

IMO you'd be better off trying ... memantine. If you're adventurous, anyway. Check out the dr-bob experiences.

All that noradrenergic potentiation doesn't sound good and must do a number on sleep quality ... besides probably running into the same barriers long-term that you get with amphetamine for mood.