The prohormone 19-norandrostenedione displays selective androgen receptor modulator (SARM) like properties after subcutaneous administration.
from PubMed: myostatin by Diel P, Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schänzer W, Schleipen B, Thevis M, Vollmer G, Zierau O
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The prohormone 19-norandrostenedione displays selective androgen receptor modulator (SARM) like properties after subcutaneous administration.

Toxicol Lett. 2008 Feb 2;

Authors: Diel P, Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schänzer W, Schleipen B, Thevis M, Vollmer G, Zierau O

One of the most frequently misused steroid precursors (prohormones) is 19-norandrostenedione (4-estrene-3,17-dione, NOR), which is, after oral administration, readily metabolised to nortestosterone, also known as nandrolone (durabolin). In this study we have characterised molecular mechanisms of its action determined its tissue specific androgenic and anabolic potency after subcutaneous (s.c.) administration and investigated potential adverse effects. Receptor binding tests demonstrate that NOR binds with high selectivity to the AR. The potency of NOR to transactivate androgen receptor (AR) dependent reporter gene expression was 10 times lower as compared to dihydrotestosterone (DHT). In vivo experiments in orchiectomised rats demonstrated that s.c. treatment with NOR resulted only in a stimulation of the weight of the levator ani muscle; the prostate and seminal vesicle weights remained completely unaffected. Like testosterone, administration of NOR resulted in a stimulation of AR and myostatin mRNA expression in the gastrocnemius muscle. NOR does not affect prostate proliferation, the liver weight and the expression of the tyrosine aminotransferase gene (TAT) in the liver. Summarizing these data it is obvious that NOR, if administrated s.c. and in contrast to its metabolite nandrolone, highly selectively stimulates the growth of the skeletal muscle but has only weak androgenic properties. This observation may have relevance with respect to therapeutic aspects but also doping prevention.

PMID: 18325697 [PubMed - as supplied by publisher]

+diol

1: Endocrinology. 2007 Dec 20 [Epub ahead of print]Click here to read Links
Tissue Selectivity of the Anabolic Steroid, 19-Nor-4-Androstenediol-3{beta},17{beta}-diol in Male Sprague Dawley Rats: Selective Stimulation of Muscle Mass and Bone Mineral Density Relative to Prostate Mass.
Page ST, Marck BT, Tolliver JM, Matsumoto AM.

Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States, 98195; Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, United States, 98108 and Office of Diversion Control, Drug Enforcement Administration, Department of Justice, Arlington, VA, United States, 22202.

Stimulation of prostate growth is a major concern with testosterone therapy in older hypogonadal men. As a result, non-steroidal selective androgen receptor modulators (SARMs) with anabolic activity but less prostate stimulation are being developed. Anabolic steroids might exhibit similar tissue selectivity. We hypothesized the anabolic steroid 19-nor-4-androstenediol-3beta,17beta-diol (3beta,19-NA)) would increase muscle, lean body mass (LBM), and bone mineral density (BMD) with little stimulation of prostate growth. Male Sprague Dawley rats were implanted with silastic capsules containing 3beta,19-NA (4,8 or 16 cm), dihydrotestosterone (DHT) (8cm), 19-nortestosterone (19-NT) (16cm) or four empty capsules after undergoing either a sham-operation (Intact) or orchidectomy (ORX). Serum gonadotropins, measured after 4, 8 or 24 weeks of treatment, were significantly lower in 3beta,19-NA-treated versus untreated, intact and ORX rats (P<0.05), and testosterone was lowered by 3beta,19-NA-treatment of intact animals. LBM and BMD were assessed after 20 weeks, and 4 weeks later rats were sacrificed for levator ani muscle (LA) and prostate weights. Compared to ORX rats, 3beta,19-NA-treated rats had dose-dependent higher LA weights, LBM and BMD, which were similar to intact and DHT-treated rats at the highest 3beta,19-NA dose. In contrast, prostate weights in all 3beta,19-NA-treated groups were similar to ORX rats and lower than intact, DHT- and 19-NT-treated rats even at the highest 3beta,19-NA dose. In summary, 3beta,19-NA increases muscle and bone mass without significant stimulation of prostate growth, suggesting it may have some properties of a steroidal SARM. Anabolic steroids such as 3beta,19-NA should be studied further to determine their mechanisms of tissue selectivity and effects in men.

PMID: 18096666 [PubMed - as supplied by publisher]

Nice fit. What's the product name that contains such a substance (I'm admittedly PH illiterate)?

They're both banned, so none that I know of(legally).

There are actually nor-andro precursors available now which are not scheduled.

Yeah, but orally, you're not going to be getting these SARM-like properties.

Yes but all you need is the raw legal nor-andro material. Then whatever a consumer does with the product is up to them. I will look into this and see what the pricing on it is.

bb

keep us up to date bb

JS

I'm on it.

bb

Wait, I'm confused. How is Nordione legal?

Im just relying on Benson's overwhelming intellect and stunning good looks in the estimation of the legality of these 2 prohormones.

bb

I think these were on the 2003 amendment to the Controlled Substances Act:

`(xxvii) norandrostenediol--

`(I) 19-nor-4-androstenediol (3b, 17b-dihydroxyestr-4-ene);

`(II) 19-nor-4-androstenediol (3a, 17b-dihydroxyestr-4-ene);

`(III) 19-nor-5-androstenediol (3b, 17b-dihydroxyestr-5-ene); and

`(IV) 19-nor-5-androstenediol (3a, 17b-dihydroxyestr-5-ene);

`(xxviii) norandrostenedione--

`(I) 19-nor-4-androstenedione (estr-4-en-3,17-dione); and

`(II) 19-nor-5-androstenedione (estr-5-en-3,17-dione;

That's what I was saying. I thought you were talking about getting raw Nordione, not percursors to it.

Looks like those prohormones listed in the research are banned.

bb

They are. That's what I've been saying.

Benson was talking about legal precursors to them like Norandrostene-3b-Ol, 17-One.

dIG.

Oh well too bad. I dont know what effectiveness there would be if you started using a precursor.

bb

Cough, umm anyone tried sourcing raws where nordione is legal?

Good luck getting them here. Chinese have increased customs inspections for all exports coming out then you still have to deal w/US customs coming in. And the Chinese are attempting to cut off their imports (coming in) too & they are attempting to restrict flow of raw materials to the hormone and peptide manufacturers too; some manufacturers are shutting down b/c they cant get the materials they need to produce hormones/peptides.

bb