We are pumped to have Pat here as a more regular part of the forums.
If you are not familiar with Pat Arnold, you've been living under a rock and should question your membership here
Full Version: A Big Welcome to ErgoPharm
Welcome!
We are pumped to have Pat here as a more regular part of the forums.
If you are not familiar with Pat Arnold, you've been living under a rock and should question your membership here
We are pumped to have Pat here as a more regular part of the forums.
If you are not familiar with Pat Arnold, you've been living under a rock and should question your membership here
thank you jeebus! Welcome back PA!
Welcome PA.
bb
bb
Welcome back!
One thing I did not go back and get that I wanted was one of your T's....will those be available anywhere?
One thing I did not go back and get that I wanted was one of your T's....will those be available anywhere?
Wow just in time for 1-ad relaunch. I also saw a nice interview with PA today talking about him playing a part in Bonds's success.
Welcome PA!
Welcome PA!
Pat to the baseball hall of fame?
Welcome back.
Welcome back.
QUOTE(chemgoddess1 @ Mar 14 2008, 05:58 AM) [snapback]465721[/snapback]
Welcome back!
One thing I did not go back and get that I wanted was one of your T's....will those be available anywhere?
One thing I did not go back and get that I wanted was one of your T's....will those be available anywhere?
t-shirts are pretty much sold out
QUOTE(ozzman @ Mar 14 2008, 06:12 AM) [snapback]465727[/snapback]
Pat to the baseball hall of fame?
Welcome back.
Welcome back.
hall of SHAME
much cooler than the hall of fame
I always get those two confused.
Can we have original AMP back...please...my last bottle is dwindling and I only use it for special occasions
Can we have original AMP back...please...my last bottle is dwindling and I only use it for special occasions
I haven't been keeping up with the latest news. Is the original AMP not being produced anymore? If so time to stock up.
BTW welcome PA!
BTW welcome PA!
Welcome.
I have tried AMP v2 and all I can say is: congratulations. It works very well. The only thing I would put out of the product would be kaempherol, since many of us take this product to get focus and engergy - and not for fat loss - and don't want to tamper with our thyroid funcion.
I have tried AMP v2 and all I can say is: congratulations. It works very well. The only thing I would put out of the product would be kaempherol, since many of us take this product to get focus and engergy - and not for fat loss - and don't want to tamper with our thyroid funcion.
QUOTE(ozzman @ Mar 14 2008, 06:54 AM) [snapback]465739[/snapback]
I always get those two confused.
Can we have original AMP back...please...my last bottle is dwindling and I only use it for special occasions
Can we have original AMP back...please...my last bottle is dwindling and I only use it for special occasions
you don't like AMP2?
I like the new AMP2 much better than the old one. I dunno why people are carrying on so much about the kaempherol, and issue with thyroid. I wouldn't have thought it does all too much to your thyroid, nothing like thyro cuts II or thyro tabs or the other stuff out there. Wouldn't you liken the degree of thyroid manipulation of kaem to a similar degree to bacopa?
Welcome Pat.
And may I say- it's about farkin' time.
And may I say- it's about farkin' time.
I like the clean stimulation it gives...and when you mix it with phenibut the effects are amazing.
I am not sure about the kaempherol issue..and as others say not in it for the fat loss.
Another stack I enjoy is AMP and Clear Edge, particularly on poker nights...I wouldn't want to be sweating then
I am not sure about the kaempherol issue..and as others say not in it for the fat loss.
Another stack I enjoy is AMP and Clear Edge, particularly on poker nights...I wouldn't want to be sweating then
QUOTE(methodice @ Mar 14 2008, 07:27 AM) [snapback]465750[/snapback]
I like the new AMP2 much better than the old one. I dunno why people are carrying on so much about the kaempherol, and issue with thyroid. I wouldn't have thought it does all too much to your thyroid, nothing like thyro cuts II or thyro tabs or the other stuff out there. Wouldn't you liken the degree of thyroid manipulation of kaem to a similar degree to bacopa?
the dose of kaempferol in there is not extreme, so you should not experience excessive thyroid hormone activity
Hello!
Hey
What do you say?
It's PA...
Have a nice day.
I've enjoyed rummaging through some of your old posts and more recent stuff at other boards, good to have you posting here again. Welcome.
EDIT: Damn, that was ghey... before someone else beats me to it
What do you say?
It's PA...
Have a nice day.
I've enjoyed rummaging through some of your old posts and more recent stuff at other boards, good to have you posting here again. Welcome.
EDIT: Damn, that was ghey... before someone else beats me to it
QUOTE(dashforce @ Mar 14 2008, 09:57 AM) [snapback]465806[/snapback]
Hey
What do you say?
It's PA...
Have a nice day.
I've enjoyed rummaging through some of your old posts and more recent stuff at other boards, good to have you posting here again. Welcome.
EDIT: Damn, that was ghey... before someone else beats me to it
What do you say?
It's PA...
Have a nice day.
I've enjoyed rummaging through some of your old posts and more recent stuff at other boards, good to have you posting here again. Welcome.
EDIT: Damn, that was ghey... before someone else beats me to it
+1.
I've been digging through a lot of old threads and posts were generally of much higher quality several years back (WRT in depth discussion of novel ideas) and PA was one of the regular contributors.
I'll add that I sure as Hell wasn't one of the aforementioned but appreciate it all none the less.
Welcome back, Patrick!
QUOTE(ChemicalPA @ Mar 14 2008, 10:46 AM) [snapback]465763[/snapback]
the dose of kaempferol in there is not extreme, so you should not experience excessive thyroid hormone activity
The problem is that I like the product so much (no joking) that I want to use it on the long run and even if it doesn't tamper with the thyroid so much I am not sure this wouldn't cause problems on the long run.
By the way, does AMP2 raise libido or is it just me? I'd swear it does.
QUOTE(ozzman @ Mar 14 2008, 10:39 AM) [snapback]465756[/snapback]
I like the clean stimulation it gives...and when you mix it with phenibut the effects are amazing.
How much phenibut are you taking? Phenibut on its own is not that great, does its effect change considerably when you stack it with AMP2? On the other hand, if you need X gr of phenibut in order to notice its effects on its own, how much do you need when taking it along with AMP2? X/2? x/4?
By the way, I have just discovered that kaempferol increases cAMP - and not only thyroid hormones - so who knows if AMP2 psychoactive effects might be less significant if it were removed.
QUOTE
Diabetes. 2007 Mar;56(3):767-76.Click here to read Links
The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA, Bianco AC.
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, HIM Bldg. #643, Boston, MA 02115, USA.
Disturbances in energy homeostasis can result in obesity and other metabolic diseases. Here we report a metabolic pathway present in normal human skeletal muscle myoblasts that is activated by the small polyphenolic molecule kaempferol (KPF). Treatment with KPF leads to an approximately 30% increase in skeletal myocyte oxygen consumption. The mechanism involves a several-fold increase in cyclic AMP (cAMP) generation and protein kinase A activation, and the effect of KPF can be mimicked via treatment with dibutyryl cAMP. Microarray and real-time PCR studies identified a set of metabolically relevant genes influenced by KPF including peroxisome proliferator-activated receptor gamma coactivator-1alpha, carnitine palmitoyl transferase-1, mitochondrial transcription factor 1, citrate synthase, and uncoupling protein-3, although KPF itself is not a direct mitochondrial uncoupler. The cAMP-responsive gene for type 2 iodothyronine deiodinase (D2), an intracellular enzyme that activates thyroid hormone (T3) for the nucleus, is approximately threefold upregulated by KPF; furthermore, the activity half-life for D2 is dramatically and selectively increased as well. The net effect is an approximately 10-fold stimulation of D2 activity as measured in cell sonicates, with a concurrent increase of approximately 2.6-fold in the rate of T3 production, which persists even 24 h after KPF has been removed from the system. The effects of KPF on D2 are independent of sirtuin activation and only weakly reproduced by other small polyphenolic molecules such as quercetin and fisetin. These data document a novel mechanism by which a xenobiotic-activated pathway can regulate metabolically important genes as well as thyroid hormone activation and thus may influence metabolic control in humans.
PMID: 17327447 [PubMed - indexed for MEDLINE]
The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA, Bianco AC.
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, HIM Bldg. #643, Boston, MA 02115, USA.
Disturbances in energy homeostasis can result in obesity and other metabolic diseases. Here we report a metabolic pathway present in normal human skeletal muscle myoblasts that is activated by the small polyphenolic molecule kaempferol (KPF). Treatment with KPF leads to an approximately 30% increase in skeletal myocyte oxygen consumption. The mechanism involves a several-fold increase in cyclic AMP (cAMP) generation and protein kinase A activation, and the effect of KPF can be mimicked via treatment with dibutyryl cAMP. Microarray and real-time PCR studies identified a set of metabolically relevant genes influenced by KPF including peroxisome proliferator-activated receptor gamma coactivator-1alpha, carnitine palmitoyl transferase-1, mitochondrial transcription factor 1, citrate synthase, and uncoupling protein-3, although KPF itself is not a direct mitochondrial uncoupler. The cAMP-responsive gene for type 2 iodothyronine deiodinase (D2), an intracellular enzyme that activates thyroid hormone (T3) for the nucleus, is approximately threefold upregulated by KPF; furthermore, the activity half-life for D2 is dramatically and selectively increased as well. The net effect is an approximately 10-fold stimulation of D2 activity as measured in cell sonicates, with a concurrent increase of approximately 2.6-fold in the rate of T3 production, which persists even 24 h after KPF has been removed from the system. The effects of KPF on D2 are independent of sirtuin activation and only weakly reproduced by other small polyphenolic molecules such as quercetin and fisetin. These data document a novel mechanism by which a xenobiotic-activated pathway can regulate metabolically important genes as well as thyroid hormone activation and thus may influence metabolic control in humans.
PMID: 17327447 [PubMed - indexed for MEDLINE]
QUOTE(ChemicalPA @ Mar 14 2008, 10:29 AM) [snapback]465729[/snapback]
t-shirts are pretty much sold out
Pretty much.....so does that mean there might be one or two still around??
PA --
Is there a place we can pose questions directed to you/your published content but not specifically Ergopharm? For example, I enjoy reading your work in MD, but if I wanted to pose a question I wouldn't want to litter your forum here. Will you be actively participating in the other forums as well?
Is there a place we can pose questions directed to you/your published content but not specifically Ergopharm? For example, I enjoy reading your work in MD, but if I wanted to pose a question I wouldn't want to litter your forum here. Will you be actively participating in the other forums as well?
Patrick! It's good to see you again.
I'll check out AMP2, as I was a fan of the original (and need the motivation, desperately, for work).
I'll check out AMP2, as I was a fan of the original (and need the motivation, desperately, for work).
QUOTE(dashforce @ Mar 14 2008, 04:05 PM) [snapback]465926[/snapback]
PA --
Is there a place we can pose questions directed to you/your published content but not specifically Ergopharm? For example, I enjoy reading your work in MD, but if I wanted to pose a question I wouldn't want to litter your forum here. Will you be actively participating in the other forums as well?
Is there a place we can pose questions directed to you/your published content but not specifically Ergopharm? For example, I enjoy reading your work in MD, but if I wanted to pose a question I wouldn't want to litter your forum here. Will you be actively participating in the other forums as well?
I reckon do it here. It will keep it more clean. Other forums Q and A with PA thread have some good questions, so many silly questions, and no-one really joins in in answering from their own knowledge. It's just Pat answering , one at a time once he gets around to doing it. If we have a similar Q and A thread with Pat here you will find some interesting questions and people other than Pat will chime in too.
Welcome back Pat! O.K. now for my complaint. No more Blueberry GF Pro? What happened did the Mitchell Commission recommend the banning of blueberries?
JD
JD
Dude welcome back!
Why the hell did you all quit making Banana Mass Meal?
Why the hell did you all quit making Banana Mass Meal?
QUOTE(dashforce @ Mar 14 2008, 04:05 PM) [snapback]465926[/snapback]
PA --
Is there a place we can pose questions directed to you/your published content but not specifically Ergopharm? For example, I enjoy reading your work in MD, but if I wanted to pose a question I wouldn't want to litter your forum here. Will you be actively participating in the other forums as well?
Is there a place we can pose questions directed to you/your published content but not specifically Ergopharm? For example, I enjoy reading your work in MD, but if I wanted to pose a question I wouldn't want to litter your forum here. Will you be actively participating in the other forums as well?
you can ask me a question here
how do i subscribe to threads on this board so i can be notified when there are updates?
Top right of the thread -- options -- track this topic (subscribe to this forum might be a better option, as you're the forum leader).
Here's a handful of Qs I thought up in reference to your recent MD articles --
You didn't mention anything about potential progestin activity with the epitiostanol drugs. Is there a chance?
Is there a general way to recognize potential for progestin activity? What changes if it loses the epithio -> DMT like you suggested?
Any guesses as to half-life?
These orals don't seem to be having ANY of the much hyped anti-gyno effects that the parent compound has. Do you attribute this to (again) breakdown to DMT, or does the methylation otherwise change the physiological efffects? We have a thread here somewhere about the changes that occur with 17aa of a steroid, but not a whole lot of conclusions have been drawn.
Thanks -- feel free to be technical if it's warranted.
EDIT: And I am referring to the brand with tests that support it being the genuine artifact, not the one whose GCMS appears suspiciously like tren. In that case, progestin activity would be expected of course.
Here's a handful of Qs I thought up in reference to your recent MD articles --
You didn't mention anything about potential progestin activity with the epitiostanol drugs. Is there a chance?
Is there a general way to recognize potential for progestin activity? What changes if it loses the epithio -> DMT like you suggested?
Any guesses as to half-life?
These orals don't seem to be having ANY of the much hyped anti-gyno effects that the parent compound has. Do you attribute this to (again) breakdown to DMT, or does the methylation otherwise change the physiological efffects? We have a thread here somewhere about the changes that occur with 17aa of a steroid, but not a whole lot of conclusions have been drawn.
Thanks -- feel free to be technical if it's warranted.
EDIT: And I am referring to the brand with tests that support it being the genuine artifact, not the one whose GCMS appears suspiciously like tren. In that case, progestin activity would be expected of course.
QUOTE(dashforce @ Mar 19 2008, 03:03 PM) [snapback]466873[/snapback]
Top right of the thread -- options -- track this topic (subscribe to this forum might be a better option, as you're the forum leader).
Here's a handful of Qs I thought up in reference to your recent MD articles --
You didn't mention anything about potential progestin activity with the epitiostanol drugs. Is there a chance?
Is there a general way to recognize potential for progestin activity? What changes if it loses the epithio -> DMT like you suggested?
Any guesses as to half-life?
These orals don't seem to be having ANY of the much hyped anti-gyno effects that the parent compound has. Do you attribute this to (again) breakdown to DMT, or does the methylation otherwise change the physiological efffects? We have a thread here somewhere about the changes that occur with 17aa of a steroid, but not a whole lot of conclusions have been drawn.
Thanks -- feel free to be technical if it's warranted.
EDIT: And I am referring to the brand with tests that support it being the genuine artifact, not the one whose GCMS appears suspiciously like tren. In that case, progestin activity would be expected of course.
Here's a handful of Qs I thought up in reference to your recent MD articles --
You didn't mention anything about potential progestin activity with the epitiostanol drugs. Is there a chance?
Is there a general way to recognize potential for progestin activity? What changes if it loses the epithio -> DMT like you suggested?
Any guesses as to half-life?
These orals don't seem to be having ANY of the much hyped anti-gyno effects that the parent compound has. Do you attribute this to (again) breakdown to DMT, or does the methylation otherwise change the physiological efffects? We have a thread here somewhere about the changes that occur with 17aa of a steroid, but not a whole lot of conclusions have been drawn.
Thanks -- feel free to be technical if it's warranted.
EDIT: And I am referring to the brand with tests that support it being the genuine artifact, not the one whose GCMS appears suspiciously like tren. In that case, progestin activity would be expected of course.
androgens that have high progestational activity are usually 19nors, especially 17alpha alkylated 19-nors. I would not expect dht derivatives such as dmt and epithio to be very progestational. Half life most likely typical of other methylated orals
i have not heard of epithio aggravating gyno.
QUOTE(ChemicalPA @ Mar 19 2008, 05:02 PM) [snapback]466845[/snapback]
you can ask me a question here
how do i subscribe to threads on this board so i can be notified when there are updates?
how do i subscribe to threads on this board so i can be notified when there are updates?
Hit the grey option tab in the upper right side of the thread (right across from the thread title when reading the thread).
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