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Full Version: What in the hell? Methylphenidate IMPROVES sleep?
Mind and Muscle Forums > Chemically Correct > Neuroscience, Health & Longevity
krazyj
http://www.ncbi.nlm.nih.gov/pubmed/1836331...Pubmed_RVDocSum

Sleep in adults with attention deficit hyperactivity disorder (ADHD) before and during treatment with methylphenidate: a controlled polysomnographic study.
Sobanski E, Schredl M, Kettler N, Alm B.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany. esther.sobanski@zi-mannheim.de

STUDY OBJECTIVES: Sleep problems are frequently associated with childhood ADHD, as indicated by numerous polysomnographic investigations showing increased nocturnal movements, reduced sleep efficiency, and decreased percentage of REM sleep (although findings are not consistent over all studies). Data on objective and subjective sleep parameters in adults with ADHD are sparse, and to date the impact of stimulants, the most widely used pharmacological treatment for ADHD, on sleep in adults with ADHD has not been examined. Thus the objectives of our study were to assess objective and subjective sleep parameters in adults with ADHD and the impact of stimulant medication on sleep. DESIGN: Two-group comparison and open-label therapy study. PARTICIPANTS: We enrolled 34 nonmedicated patients with ADHD, of whom 24 were without current comorbid psychiatric disorders, and 34 sex- and gender-matched control subjects without current psychiatric disorders or psychotropic medication. INTERVENTIONS: Ten patients were treated with methylphenidate over > or =26 days with a mean daily dose of 36.7 +/- 11.2 mg. MEASUREMENTS: Polysomnographic recording over 2 consecutive nights as well as assessments of subjective sleep parameters were performed in all patients and controls before treatment and reassessed in those patients receiving methylphenidate. RESULTS: Compared to controls untreated patients showed increased nocturnal activity, reduced sleep efficiency, more nocturnal awakenings and reduced percentage of REM sleep. Treatment with methylphenidate resulted in increased sleep efficiency as well as a subjective feeling of improved restorative value of sleep. CONCLUSIONS: Sleep problems in patients with ADHD continue from childhood to adulthood, with similar objective sleep characteristics in adults and children with ADHD. Medication with methylphenidate appears to have beneficial effects on sleep parameters in adults with ADHD.


Hmm... So if MPH helps sleep quality in ADHD persons, wouldnt that go against the theory of it being responsible for adrenal fatigue and chronic sleep deprevation and blahblahblah? Hell, wouldnt it help PREVENT against adrenal fatigue?
october_red

MPH is a corrective measure for ADHD. It's not a huge surprise that it might help normalize a disjointed circadian rhythm.

In normal, healthy adults, it is simply crank.
Frangible
1. Lack of dopamine = RLS = impaired sleep
2. Complete tolerance to the wakefulness effect of stims has been demonstrated in humans in every study on it I've read for a therapeutic dose in the context of ADD. For the first month or so at a given dose, sleep can be impaired.
3. "Adrenal fatigue" isn't a recognized disease, but the underlying etiology of what you describe can be treated with stimulants and oral corticosteroids. In terms of prevention, stress reduction works, and in human studies therapeutic stimulant dosing in patients with ADD does not have a significant effect on cortisol or stress either way. This goes against the treating ADD = your brain explodes from cortisol brotelligence here, inorite?
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