Alright M&M, time to stand tall and make a difference.

This website is home to of some of the brightest minds on the web, and we need to recruit our collective intelligence and make a difference.

On Monday afternoon I was picking up the step-son from elementary school, when I had a life changing experience. A women in her late 40's was standing in the lobby waiting to pick up her daughter. Her first reaction was to approach me and rub my head, asking, "how do you do that?"

I shave my head on a daily basis. This women has been diagnosed with ovarian cancer, and was seeking a solution to keep her head shaved.

I say we gave her more than that. When her daughter approached, the young girls smile struck a chord in my heart. Instantly, the thought of the excitement on this girls faced dashed by the news that her mother has passed gave me an instillment of motivation I have never felt before.

I have decided to devote all my spare time, and a good amount of my not so spare time to researching treaments to help this women survive. I know there is plenty of info here and other places on alternative treatments etc.

Im not asking for your help in this specific situation, but I am asking your help in assisting mankind in general by researching and compiling info, and creating alternative yet effective treatment options for people in this same scenario. This could be YOUR mother. Or even worse, it could be your daughters face showing the despair when hearing similar news.

If were spending time researching on the web anyways, lets make a difference.





“It is not the critic who counts; not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better. The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood, who strives valiantly; who errs and comes short again and again; because there is not effort without error and shortcomings; but who does actually strive to do the deed; who knows the great enthusiasm, the great devotion, who spends himself in a worthy cause, who at the best knows in the end the triumph of high achievement and who at the worst, if he fails, at least he fails while daring greatly. So that his place shall never be with those cold and timid souls who know neither victory nor defeat.”
Teddy Roosevelt



Any takers?

There have been a number of threads about this. First, you need to find out if this woman even wants any help. Most people laugh at the idea of some plants being able to help them beat cancer.

But, that said, do a search and you'll find a lot. There was also a very good thread at avantlabs.com on this as well.

I sympathize with your experience. Anyone who has been to the children's ward of a cancer treatment center cannot leave without feeling a heavy burden on one's shoulders, and being asked for a kind of help from a stranger with cancer (and, with a child) must have been quite an emotional experience. Although a "cancer thread" is a good idea, the types of threads that seem to generate the most info seem to be rather ad-hoc, and fit to a particular set of circumstances.

M&M is not good at "centralizing" information on any one given topic, even one as large and important as this, because most members do not see their posts as part of a larger project (i.e. a wiki) but rather as a series of relatively unrelated meaningful correspondences. I hope this thread flourishes, but like Odium pointed out, the info on the topic is spread far and wide across the forum.

I asked if she would like to read some research, and possibly try some alternative treatments. Ive read all the cancer threads, some very good info there.

As far as MM not being good at centralizing info, is that the way it has to be?

I was trying to invoke a little emotion to provide some motivation to take this thread beyond the normal realm of what is posted here. I think it might be a better use of time compared to debating whether one should take teaspoons of HC, becuase they are meme and now are self-diagnosed with "adrenal fatigue".

It seems to be the ailment of the week at this point.

As far as Odiums post, I found nothing of value in it. Yes, I know to do a search, pretty basic advice there. And before anyone would go to these lengths to help someone, dont you think they would O.K. it with the person in question?
I normally would not make a personal comments like this, but it seems all of Odiums posts lately have been either derogatory or non-constructive.

In the other threads, someone states "oh yeah, circumin and lactoferrin FTW. Here's an abstract" and that is pretty much where it is left.

I want to take this thread to the next level---actually producing effective treatments from our collective research. If im dreaming then oh well; refer to Roosevelts quote.

I asked if she would like to read some research, and possibly try some alternative treatments. Ive read all the cancer threads, some very good info there.

As far as MM not being good at centralizing info, is that the way it has to be?

I was trying to invoke a little emotion to provide some motivation to take this thread beyond the normal realm of what is posted here. I think it might be a better use of time compared to debating whether one should take teaspoons of HC, becuase they are meme and now are self-diagnosed with "adrenal fatigue".

It seems to be the ailment of the week at this point.

As far as Odiums post, I found nothing of value in it. Yes, I know to do a search, pretty basic advice there. And before anyone would go to these lengths to help someone, dont you think they would O.K. it with the person in question?
I normally would not make a personal comments like this, but it seems all of Odiums posts lately have been either derogatory or non-constructive.

In the other threads, someone states "oh yeah, circumin and lactoferrin FTW. Here's an abstract" and that is pretty much where it is left.

I want to take this thread to the next level---actually producing effective treatments from our collective research. If im dreaming then oh well; refer to Roosevelts quote.

Something I put together for a friend a while back:


General health supplements

Multi-vitamin (make sure she's taking a GOOD multi)
Probiotics
Essential fats

Along with that:

Greens beverage (Greens plus or any of the various "greens" type drinks - can get this at any health food store)- take a couple of times per day - this will help alkalinize the body.

Garlic (just buy from the store and take a clove per day)

Vitamin C - mega doses preferable - can work up to 10000 milligrams per day - a minimum of 2500 milligrams. I'd use the buffered C

B-complex vitamins- B-50 - one per day

Magnesium - Just about all people with disease are severely deficient

Vitamin D- Just about all people with disease are severely deficient. Take 5000 IU/day D3 minimum + try to get in the sun or use a tanning bed if possible

melatonin: 1-3 mg per day taken before bed. Does a variety of great things to normalize hormones that regulate the circadian rhythm - Particularly in menopausal or post-menopausal women.
Info: http://www.lef.org/magazine/mag2004/jan200...elatonin_01.htm

Green Tea extract 1000 mg/day (50% ecgc) - Use the 95%+ extract

Moderately heavy hitters - (these supplements are all "healthy" and can be taken indefinitely, but they also all have specific anti-cancer effects):

beta glucan - 1000 mg once per day - Is a primary treatment for cancer in Asia. Stimulates the immune system and increases white blood cell count.

Info: http://www.cancure.org/beta_glucan.htm

lactoferrin 300-500 mg/day - Is great for everything. Is a subfraction of whey with the best documented anti-viral, anti-microbial, anti-cancer and immune modulating/enhancing effects. Is also great for rebalancing intestinal flora.

http://www.lef.org/magazine/mag2001/apr200...port_lacto.html

IP6- Tumor cells utilize iron as a primary growth factor and IP-6 chelates iron out of cancer cells while leaving normal cells alone. Here is a paper on it:
http://jn.nutrition.org/cgi/content/full/133/11/3778S

grapeseed extract: 200 mg/day Is an antioxidant and also increases availability of a critical protein, Cip1/p21, in tumors that effectively freezes the cell cycle, and often pushes a cancer cell to self destruct.

Info: http://www.oralchelation.com/ingred/grapeseedextract.htm

Resveratrol: Does several amazing things for all sorts of conditions. Decreases tumor promotion activity by inhibiting cyclooxygenase-1 (COX-1) [4,11,12], an enzyme that converts arachidonic acid to pro-inflammatory substances that stimulate tumor-cell growth

http://www.lef.org/resveratrol/

Ellagic Acid 500 mg day- Found in 46 different fruits and nuts such as blackberries, raspberries, strawberries, and cranberries. Acts as a scavenger to "bind" cancer-causing chemicals, making them inactive. It inhibits the ability of other chemicals to cause mutations in bacteria.
Info:
http://alternativecancer.us/ellagicacid.htm


From my research the following Paw Paw, Protocel, or Cesium have very strong anti-tumor properties but are not things a healthy person would probably want to take all of the time because they do have very specific effects on aspects of physiology.....not necessarily side effects....but they are strong at what they do. I would choose one of these in addition to the above general supps list.

Paw Paw: is a POWERFUL natural plant based supplement. It is taken from the leaves and stems of a tree called a paw paw tree. There has been quite a bit of research done on it. The guy who developed it, Jerry Mclaughlin, worked for Purdue University studying it his entire career and was involved with drug companies isolating the various actives out of it. It works by lowering cellular ATP levels in highly active (cancer) cells. This effectively starves the cell to death. He has cased studies of over 100 patients with really good results. The CA125 levels (a blood marker for cancer activity) were reduced by as much as 66% in only one week! The only side effect is possible stomach ache. The stomach lining cells are also highly active cells. If the stomach problems are too bad you can switch to Protocel, which is another natural treatment that works by the same mechanism...but is a bit more expensive. The drawback to using protocel is you can't take high dose anti-oxidants with it. Another benefit is Paw Paw only costs about $30/month.

Go to page 5 of this document to read the case studies on paw paw:
http://www.pawpawresearch.com/pawpaw-trials1.pdf

Paw Paw:
info: http://www.pawpawresearch.com

Cesium: is a type of alkaline mineral. It works by lowering the PH in the body and makes the cancer cells alkaline. This limits the intake of glucose in the cells and basically starves the cell. It is inexpensive but the drawback is that care needs to be taken to ensure potassium levels are good while taking it and I wouldn't feel comfortable recommending this unless you're willing to call and consult with the vendor that sells it, who does offer consulting for free. There is a popular 33 day protocol using Cesium you can read about here that has vendor links:

http://www.cancertutor.com/Cancer/Cesium_Barefoot.html

The most effective Cesium administration involves mixing it with Dmso and applying it to the skin and DMSO will make a person smell like garlic. - but anyway, that is definitely also an option. You can read about that here:

http://www.cancertutor.com/Cancer/Alkaline.html

Protocel: (also called Cancell) is a blend that was put together by a researcher nearly 20 years ago...it functions as an anti-oxidant but is actually a blend of several things so it's kind of half supplement/half drug. It has a big following in the alternative crowd. It works by the same mechanism as Paw Paw....lowering ATP levels in highly active cells. Everything I've read has not shown any side effects and it has a big following for many years. The drawback is you cant take high dose anti-oxidants like vitamin C with it because those vitamins cancel out it's effectiveness. You can read more about it here:

http://www.cancertutor.com/Cancer/Protocel.html

and order it here:

http://www.webnd.com/index.php

Some people even recommend both Protocel and Paw Paw be used together....start with the protocel for 3-5 weeks and then add in Paw Paw.


Some other general recommendations:

- Eat a low sugar diet with high intake of veggies
- drink Essiac or Paul D'Arco Tea
- Mix freshly squeezed lemons or limes and mix with tea or water (boosts alkalinity)
- Consume vegetable juice (v-8 or freshly squeezed juice like celery juice daily)
- Use tums or other acid reducers liberally (they consist of calcium carbonate and magnesium which both boost alkalinity)
- buy some apricot kernels at the health food store and eat up to 20 per day (they contain vitamin b-17 which has long been a popular alternative cancer treatment)
- use the spice turmeric liberally on food
- a good meal that is actually recommended as a treatment itself by some practitioners is to mix up a half cup of cottage cheese with several tablespoons of flax seed oil.

Also lots more info here: http://www.cancertutor.com

There are lots of supplements with anti-cancer activity, but the general idea is to boost the health from the inside out.

Thats what im talkin bout...Thanks

Resveratrol and some other stilbene-like compounds are also metabolized by tumor-specific CYP1B1 into potent tyrosine kinase inhibitors, which is likely a large determinant of their underlying anti-tumor pharmacology, in addition to modulation of cell energy pathways and SIRT. Depending on the specific cancer and context, I wouldn't be surprised if mega-dosing (or infusing) resveratrol could offer profound therapeutic efficacy.

I figured i would add something that hasnt been posted in the thread already as Kellyb outlined most of the main players.


Asian Pac J Allergy Immunol. 2006 Mar;24(1):33-45.Links
Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment.

Cancer Immunol Immunother. 2006 Oct;55(10):1258-66. Epub 2005 Dec 16. Links
Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses.Gao Y, Zhang D, Sun B, Fujii H, Kosuna K, Yin Z.
Section of Rheumatology, Department of Medicine, Yale School of Medicine, CAB Building, Room 517, 300 Cedar Street, 208031, New Haven, CT 06520-8031, USA.

Active hexose correlated compound (AHCC) is a mixture of polysaccharides, amino acids, lipids and minerals derived from cocultured mycelia of several species of Basidiomycete mushrooms. AHCC has been implicated to modulate immune functions and plays a protective role against infection. However, the potential role of AHCC in tumor immune surveillance is unknown. In this study, C57BL/6 mice were orally administered AHCC or water, followed by tumor cell inoculation. We showed that compared to pure water-treated mice, AHCC treatment significantly delayed tumor development after inoculation of either melanoma cell line B16F0 or lymphoma cell line EL4. Treatment with AHCC enhanced both Ag-specific activation and proliferation of CD4(+) and CD8(+) T cells, increased the number of tumor Ag-specific CD8(+) T cells, and more importantly, increased the frequency of tumor Ag-specific IFN-gamma producing CD8(+) T cells. Interestingly, AHCC treatment also showed increased cell number of NK and gammadelta T cells, indicating the role of AHCC in activating these innate-like lymphocytes. In summary, our results demonstrate that AHCC can enhance tumor immune surveillance through regulating both innate and adaptive immune

Anticancer Drugs. 1998 Apr;9(4):343-50.Links
Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma.

Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study.
Matsui Y. J Hepatol 2002 Jul;37(1):78-86.


Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum Reishi?
Int J Surg Pathol. 2007 Apr;15(2):180-6. Department of Pathology, Queen Elizabeth Hospital, Wylie Road, Kowloon, Hong Kong.
Complete regression of high-grade lymphoma is extremely rare. We report 1 such case that might have been conceivably mediated by reishi. A 47-year-old man presented with epigastric pain. Endoscopy revealed a large gastric ulcer, which on biopsy was diagnostic of large B-cell lymphoma. At gastrectomy 11 days later, no evidence was found of large B-cell lymphoma despite thorough sampling. Instead, there was a dense and permeative infiltrate of CD3(+) CD8(+) cytotoxic small T lymphocytes spanning the whole thickness of the gastric wall. In situ reverse transcription polymerase chain reaction for T-cell receptor beta-chain family did not detect a monoclonal T-cell population. We postulate that the cytotoxic T cells may represent an active host-immune response against the large B-cell lymphoma that resulted in a complete regression. On questioning, the patient had taken megadoses of reishi, which might have triggered the successful immune reaction.

Anti cancer effects of Ganoderma lucidum: a review of scientific evidence.
Nutr Cancer. 2005;53(1):11-7. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, SAR, China.
Reishi a popular medicinal mushroom, has been used in China for longevity and health promotion since ancient times. Investigations into the anti cancer activity of reishi have been performed in both in vitro and in vivo studies, supporting its application for cancer treatment and prevention. The proposed anti cancer activity of reishi has prompted its usage by cancer patients. It remains debatable as to whether reishi is a food supplement for health maintenance or actually a therapeutic "drug" for medical proposes. Thus far there has been no report of human trials using reishi as a direct anti cancer agent, despite some evidence showing the usage of reishi as a potential supplement to cancer patients. Cellular immune responses and mitogenic reactivity of cancer patients have been enhanced by reshi, as reported in two randomized and one nonrandomized trials, and the quality of life of 65% of lung cancer patients improved in one study. The direct cytotoxic and anti-angiogenesis mechanisms of reishi have been established by in vitro studies; however, clinical studies should not be neglected to define the applicable dosage in vivo. At present, reishi is a health food supplement to support cancer patients, yet the evidence supporting the potential of direct in vivo anti cancer effects should not be underestimated

Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms.
Acta Pharmacol Sin. 2004 Nov;25(11):1387-95.
Ganoderma lucidum ( reishi ) is a medicinal fungus with a variety of biological activities. Reishi has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its effect on the immune system and anti-tumor activities. Large numbers of studies have shown that reishi modulates many components of the immune system such as the antigen-presenting cells, NK cells, T and B lymphocytes. The water extract and the polysaccharides fraction of reishi exhibited significant anti-tumor effect in several tumor-bearing animals mainly through its immune system enhancing activity. Recent studies also showed that the alcohol extract or the triterpene fraction of reishi possessed anti-tumor effect, which seemed to be related to the cytotoxic activity against tumor cells directly. Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of reishi.

Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide.
Acta Pharmacol Sin. 2004 Jun;25(6):833-8

Ganoderma lucidum (Reishi) inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3.
Int J Oncol. 2004 May;24(5):1093-9

Ganoderma lucidum (Reishi) in cancer treatment.
Integr Cancer Ther. 2003 Dec;2(4):358-64.

Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients.
Immunol Invest. 2003 Aug;32(3):201-15.
Preclinical studies have established that the Ganoderma lucidum polysaccharide (reishi) fractions have potent anti-tumor activity, which has been associated with the immuno-stimulating effects of reishi. However, it is unclear whether reishi has immuno-modulating effects in humans in vivo. This study aimed to investigate the effects of Ganopoly, the polysaccharides fractions extracted from reishi, on the immune function of advanced-stage cancer patients. Thirty-four advance-stage cancer patients were entered onto this study, and treated with 1800 mg Ganopoly (reishi), three times daily orally before meals for 12 weeks. Immune parameters (cytokines, T cell subsets, and natural killer activity) were compared between baseline and after 12-week treatment. Thirty patients are assessable for their immune functions. Treatment of reishi for 12 weeks resulted in a significant increase in the mean plasma concentrations of interleukin (IL-2), IL-6, and interferon (IFN)-gamma, whereas the levels of IL-1 and tumor necrosis factor (TNF-alpha) were significantly decreased. A marked variability among patients with advanced-stage cancer was observed in the numbers of each lymphocyte subset at baseline. The mean absolute number of CD56+ cells was significantly increased after 12-week treatment of reishi, whereas the numbers of CD3+, CD4+, and CD8+ were just marginally increased compared to baseline levels, with the CD4:CD8 T cell ratios unchanged. In addition, reishi treatment resulted in a significant increase in the mean NK activity compared to baselines. The present study indicates that Ganopoly enhanced the immune responses in patients with advanced-stage cancer. Clinical evaluations of response and toxicity are ongoing.

There are many more abstracts on different mushrooms but i would suggest adding in 2-4 grams of AHCC, and a high quality blend of mushroom extracts including reshi, maitake,cordyceps and shitake as all have immune enhancing and some straight up direct anticarcinogenic effects. Throne has a good mushroom blend for dirt cheap, and AOR has a good qualtiy AHCC.

a healthy dose of selenium would be adviasble also, ill post the study we i get back home.

DCA and lactoferrin.

Does anyone have any idea's on dosing regiments/times in relation with diet forsome of these drugs? DCA looks VERY promising, thanks Benson.

On inositol and IP6:

In rats, fasting has been shown to increase survival during chemo, if it comes to that. Cannot find the abstract at the moment.

Is radiation still used as a form of treatment?

Protective effect of intermittent fasting on the mortality of gamma-irradiated mice. (Kozubík A, Pospísil M.)
The effect of 1 to 6 weeks' adaptation to intermittent fasting (alternating periods of 24 h fasting and subsequent 24 h feeding) on the manifestations of radioresistance of mice subjected to whole-body gamma-irradiation was studied. A favourable effect of this feeding regimen on the survival of irradiated animals was observed. The optimal radioprotective effect was achieved in mice adapted to intermittent fasting for 2 to 3 weeks and irradiated after 24 h of food intake. Furthermore, it was shown that the radioresistance of the adapted organism depends on the momentary state of food intake. After renewal of the normal ad libitum feeding the adaptively induced radioresistance decreases.

Ketogenic diets and alkaline body pH. (Funny, was once riduculed for suggesting cesium at avant).

NAC+ECGC = some novel adduct that kills lung cancer cells.

Nano-particles and radio waves, still a few years off at best.

Have quite a few on low carb & cancer:



http://nmsociety.org/index.php?option=com_...9&Itemid=29

One more:

http://www.eurekalert.org/pub_releases/200...m-she031008.php

It is but not as whole-body ionizing irradiation.

Life Extension Foundation has a very comprehensive section dealing with cancer. They do not dismiss conventional treatments such as radiation, chemo or surgery but, seek to help patients get the most out of these modalities, often by suggesting pharmaceutical or nutritional/supplemental adjuncts. They also caution as to when a particular compound might interfere with a conventional treatment. Alternative therapies are covered as well.

http://www.lefcancer.org/

http://www.lef.org/protocols/

The work of Dr. Nicholas Gonzalez of NYC comes to mind. His use of pancreatic enzymes, special diets and coffee enemas are controversial and unorthodox but, perhaps worth investigating. The interview below is very interesting.

http://www.mindandmuscle.net/forum/index.p...amp;hl=gonzalez
http://www.alternative-therapies.com/at/we...fs/gonzalez.pdf

I'm currently a bio undergrad and my genetics professor is currently researching the effects of anthocyanins on tumor growth. It along with many other polyphenolic compounds, i.e. resversatrol, capsiacin, gingerol, gallic acid, epicatechins etc. are being researched for their ability to induce apoptosis in cancerous cell lines. A lot of the research is in vitro and in the beginning stages, but having done a good amount of research for a few papers, there is the potential for far more elegant cancer treatments that target the cellular machinery directly responsible for tumor growth. Wikipedia actually has a decent list of polyphenolic compounds

So, I guess you could try to get her to supplement her diet with lots of cranberries, dark choclate, green tea, raspberries, blueberries, pomegranate and red wine. I read a few studies confirming that the berry polyphenols were found in the blood after ingestion, showing they weren't excreted unused.

I'm sorry, I guess we should rehash everything that's been said over the years because you decided to start a thread. The constructiveness has already been done, that's why I said do a search...not to be dick, but to inform because you haven't been around that long. You could be constructive and start compiling all of the great information already in this forum and the one at AL.com.

And no, it's not obvious to assume that you got permission first. People who want to help don't always think that someone might not want it. I have a bit of experience with this as my mother died 2 years ago from breast cancer that plagued her for 3 years (this was her second bout with it). I did lots of research because I wanted to help and she really only humored me when I presented my findings to her on a regular basis. So, if I'm being derogatory because I wanted to save you from the immense frustration that I experienced with my mother's situation, then I'll accept being an asshole. It fucking sucks knowing I possibly could've prolonged her life maybe just long enough to see my sister get married if she had just listened to me.

It's a shame the AL.com wiki is gone, because this topic is perfect for it...a great way to fix what Dopamine pointed out. The forum model is great for storing information in conversational flow, but unless you're active in a particular thread, retrieval sucks, IMO. If M&M wants to send me a copy of their database (sans sensitive information, of course), I'd be happy to work on a text mining / data mining project to find other windows into the information here other than threaded discussions. I have a lot of wasted computational power at work I could use...and I'm looking for excuse to use Amazon's EC2 as well.

Yeah why isn't there an M&M wiki?

Ive actually been around much longer than my join date. A WIKI would be awesome